Brian VastagNov 8, 2024

Just tuned into @polybiorf fall symposium on #LongCovid and #MEcfs research. Talks are 10-15 minutes and they are a bit behind schedule.

Polybio is a small outfit run by Amy Proal, who has long thought that viral persistence is a driving factor in these chronic illnesses.

Free to watch w/ registration.

#research #medicine

https://polybio.org/fall-2024-symposium-schedule/

Fall 2024 PolyBio Symposium Schedule - PolyBio Research Foundation

PolyBio Research Foundation
Show threadBrian VastagNov 8, 2024

Will post a bit about Matthew Frank's talk on 'multiple hit model of long covid."

He's at U of Colorado.

Show threadBrian VastagNov 8, 2024
#SARSCoV2 can directly enter brain and produce inflammatory cytokines there. This molecules can produce fatigue, cognitive issues.
Show threadBrian VastagNov 8, 2024
You see initial neuroinflammation that produces long-term effects that persist after initial inflammation calms down. But leaves brain cells susceptible to quicker easier inflammation down the road. This is from mouse work, Franks says.
Show threadBrian VastagNov 8, 2024
They gave the mice a 'bacterial mimetic' after the SARSCoV2 infection. Those mice have a worse brain response than mice that didn't get infected with the virus. He calls this 'priming '
Show threadJune Casagrande
@brianvastag Thank you for sharing this. If there's any mention of sleep disruption, especially among people who had only mild covid cases and no other long-term effects, please consider posting. Asking for a friend.
Nov 8, 2024 at 9:01pmWeb