Denis - The COVID info guy -Mar 8, 2024

Virus Lingers in Blood Years After Infection | neurosciencenews.com

"SARS-CoV-2, the virus causing COVID-19, can remain in the human body long after the initial infection has subsided, with fragments found in blood for up to 14 months and in tissues for over 2 years"

#COVID19 #SARSCoV2 @auscovid19

Source: https://neurosciencenews.com/long-covid-blood-25724/

COVID's Long Haul: Virus Lingers in Blood Years After Infection - Neuroscience News

Neuroscience News provides research news for neuroscience, neurology, psychology, AI, brain science, mental health, robotics and cognitive sciences.

Neuroscience News
Show threadDaniel Keppler, PhDMar 8, 2024
@DenisCOVIDinfoguy @auscovid19 NO, the virus does not linger in patients. Long Covid patients are NOT infectious! Virus antigens or fragments are NOT full-blown functional virus particles. However, virus antigens - such as surface glycoproteins - may continue to have nefarious biological activities, apparently long after the viral infection has been neutralized. #Covid #LongCovid
Show threadCurrentBiasMar 8, 2024
@Daniel_Keppler @DenisCOVIDinfoguy @auscovid19 "In some of the samples [of connective tissue], the researchers found that the virus could be active."
Show threadDaniel Keppler, PhDMar 8, 2024
@currentbias @Daniel_Keppler @DenisCOVIDinfoguy @auscovid19 Oh darn! Now I have to read that paper! 😉🤣
Show threadDaniel Keppler, PhDMar 8, 2024
@currentbias @Daniel_Keppler @DenisCOVIDinfoguy @auscovid19 Okay! These are preliminary results presented at the Conference on Retroviruses and Opportunistic Infections on March 3, 2024. They thus have not yet been published or even submitted to peer review. Typically, it can take 3-5 years for data presented at a conference to be published and, by then, the results might be quite different. Therefore, I stand by what I said earlier.
Show threadCurrentBiasMar 8, 2024

@Daniel_Keppler @DenisCOVIDinfoguy @auscovid19 it's true, peer review is painfully slow. The implications of this work deserve attention in the meantime, though, as long as we contextualize it properly. The John Snow Project wrote an editorial about this study in September of last year:

https://johnsnowproject.org/insights/a-new-disease-paradigm/

COVID-19: A NEW DISEASE PARADIGM

What if SARS-CoV-2 continues to infect us even after the initial symptoms fade?

John Snow Project
Show threadDaniel Keppler, PhDMar 8, 2024
@currentbias @Daniel_Keppler @DenisCOVIDinfoguy @auscovid19 Thank you for this link and the wealth of information that it brings. Indeed, a lot of publications show that immune/inflammatory responses persist over longer periods (1-3 years) in human tissues. But, whether this persistence is due to the virus surviving and possibly replicating in specific tissues known as “reservoir tissues” remains to be clearly established. 1/3 #Covid #LongCovid
Show threadDaniel Keppler, PhDMar 8, 2024
@currentbias @Daniel_Keppler @DenisCOVIDinfoguy @auscovid19 Persistent infections have been observed before for viruses that have the enzymatic machinery necessary to integrate into the human genome. This is the case for the HIV-1 and HBV viruses. However, the Covid coronaviruses do not have this enzymatic machinery. On top of that the viral single-stranded RNA would be rapidly degraded inside infected cells. 2/3. #Covid #LongCovid
Show threadDaniel Keppler, PhD
@currentbias @Daniel_Keppler @DenisCOVIDinfoguy @auscovid19 Therefore, at this stage of the research it is too early to suggest that a new biological paradigm might be at play here. Let’s wait for more direct evidence of the presence of functional viral long Covid particles in human tissues.
3/3. #Covid #LongCovid #PersistentInfection
Mar 8, 2024 at 9:22amMastodon for iOS
Show threadSamMar 8, 2024

@Daniel_Keppler @currentbias @DenisCOVIDinfoguy @auscovid19
RE: long-#COVID.

Wrong. Wrong! Wrong!!

This is the time to apply common freaking sense and the precautionary principle, NOT the scientific let's wait a decade for absolute confirmed proof idiocy.

We know enough to know that long-COVID is catastrophic. And we know enough to know that hyper accelerated aging and immune destruction are too.

Know is already too late to act, but now is all we have. And any delay is catastrophic.

Show threadDaniel Keppler, PhDMar 8, 2024
@samohTmaS @Daniel_Keppler @currentbias @DenisCOVIDinfoguy @auscovid19 I fully understand your frustration with the pace of the rigorous scientific method, particularly if you have loved ones suffering from Covid complications. But, accept that the alternative approach of taking premature decision and shortcuts can be more devastating. The debacle around the anti-parasitic drug ivermectin is just one recent example. #LongCovid
Show threadsleepfreeparentMar 8, 2024

@Daniel_Keppler @samohTmaS @currentbias @DenisCOVIDinfoguy @auscovid19 no that's not what's being suggested at all.

There are actions that can and should be taken today to assess and reduce risk.

For example, we know that long COVID depletes T cells year on year (in at least some patients) and there's strong evidence in multiple papers for persistence in viral reservoirs. What other virus do you know with these two features? People who have had COVID need to know this NOW. Doctors need to start monitoring T cell counts in COVID survivors NOW. Not waiting until everybody's immune system has already given up

Show threadSamMar 8, 2024

@Daniel_Keppler @currentbias @DenisCOVIDinfoguy @auscovid19

Actually NO! The level of damage that the virus causes is so severe that the reverse is true.

By the time the average person has had #COVID three times it is already too late for society. We passed that point long ago,

We are slowly beginning to see the consequences of failure to act play out.

By next year those should be obvious to everyone. By the next year - game over. Welcome to the second dark age.