"treatment with D-mannose, a natural bioactive monosaccharide, rescues #autophagy flux, reverses the SASP, and mitigates ROS and NLRP3/Gasdermin/interleukin (IL)-1β-driven pyroptotic #epithelial cell shedding in aged mice..normal #aging affects #bladder #physiology, with aging alone increasing baseline #cellular stress & susceptibility to #infection, & suggest that #mannose supplementation could serve as a senotherapeutic to counter age-associated urothelial dysfunction"

https://www.sciencedirect.com/science/article/abs/pii/S1534580723006159?via%3Dihub