Mastodawn

El Duvelle Neuro Aug 18, 2023

My dream goal on here is to attract enough #Electrophysiologists so that we can debate things like which drives to use, nichrome or platinum wire, what gold-plating impedance, Vaseline or kwik-sil for surgery, tetrodes in or out of brain, going backwards during screening or not, which is the best recording system, rats vs mice (rats, ofc), etc.

So please tell your #Ephys colleagues to join! (Or they can also join the #NeuroMethods slack but that’s less fun)

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Alicia Izquierdo, Ph.D.Aug 18, 2023

@elduvelle_neuro this is great! I’m curious what you and other #Electrophysiologists think of dexamethasone treatment as postop care? It seems a more prevalent practice among those working with #Neuropixels but not amongst the #ephys community-at-large #EphysTip #neuroscience

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Chris Rodgers Aug 18, 2023

@alicia_izquierdo @elduvelle_neuro Dex is common in imaging preps and many NP people are in imaging labs so i wonder if that’s where it came from. haven’t tried it myself! It will suppress immune response and delay healing so it’s not a magic bullet. Also interacts badly with NSAIDs like carprofen and meloxicam. I just came off a taper of a similar drug (prednisone) for poison ivy and can confirm that it definitely suppresses inflammation :)

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Alicia Izquierdo, Ph.D.

@chrisXrodgers @elduvelle_neuro thanks Chris, you’ve validated my concerns about it! We do lens implants too and we have never used dex precisely because of the issues you raise (interaction with carprofen, immunosuppression, etc.)