El Duvelle Neuro

My dream goal on here is to attract enough #Electrophysiologists so that we can debate things like which drives to use, nichrome or platinum wire, what gold-plating impedance, Vaseline or kwik-sil for surgery, tetrodes in or out of brain, going backwards during screening or not, which is the best recording system, rats vs mice (rats, ofc), etc.

So please tell your #Ephys colleagues to join! (Or they can also join the #NeuroMethods slack but that’s less fun)

Aug 18, 2023 at 12:23pmWeb
Show threadmanishaAug 18, 2023
@elduvelle_neuro the #NeuroMethods slack is less fun and also a free-tier one which means so much of community knowledge is just lost after 90 days because of slack's free message history limit.
Show threadEl Duvelle NeuroAug 18, 2023
@manisha yes, hopefully at some point we’ll find a fix for that…
Show threadAlicia Izquierdo, Ph.D.Aug 18, 2023
@elduvelle_neuro this is great! I’m curious what you and other #Electrophysiologists think of dexamethasone treatment as postop care? It seems a more prevalent practice among those working with #Neuropixels but not amongst the #ephys community-at-large #EphysTip #neuroscience
Show threadChris RodgersAug 18, 2023
@alicia_izquierdo @elduvelle_neuro Dex is common in imaging preps and many NP people are in imaging labs so i wonder if that’s where it came from. haven’t tried it myself! It will suppress immune response and delay healing so it’s not a magic bullet. Also interacts badly with NSAIDs like carprofen and meloxicam. I just came off a taper of a similar drug (prednisone) for poison ivy and can confirm that it definitely suppresses inflammation :)
Show threadAlicia Izquierdo, Ph.D.Aug 18, 2023
@chrisXrodgers @elduvelle_neuro thanks Chris, you’ve validated my concerns about it! We do lens implants too and we have never used dex precisely because of the issues you raise (interaction with carprofen, immunosuppression, etc.)
Show threadBen KanterAug 18, 2023
@alicia_izquierdo @elduvelle_neuro our lab does not use dexamethasone with #Neuropixels 🤷‍♂️
Show threadBen KanterAug 18, 2023
@elduvelle_neuro as someone who used #Tetrodes for quite a few years in both #rats and #mice, i'd strongly urge people to use high-density #probes if possible! far more cost effective, more data, less animals, less time. tetrodes should be the exception when recording geometry or other issues demand it.
Show threadEl Duvelle NeuroAug 18, 2023
@beneuroscience They definitely seem more efficient! I’m not sure they’re the best for hippocampus recordings though, compared to tetrodes. But for most other things they seem great!