kevinboldingFrom what I can tell, folks that are successfully using #Neuropixels for either acute or chronic recordings are using the metal cap to attach to a dovetail holder. My question for #neuroscience : is there ever a reason to use the version *without* the metal cap?
The vOICe vision BCI 🧠🇪🇺@kevinbolding When low(er) weight is critical? https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8177890/
Metal microdrive and head cap system for silicon probe recovery in freely moving rodent
High-yield electrophysiological extracellular recording in freely moving rodents provides a unique window into the temporal dynamics of neural circuits. Recording from unrestrained animals is critical to investigate brain activity during natural behaviors. ...
Chris Rodgers@seeingwithsound @kevinbolding Can I slightly derail this question and ask who is doing freely moving NP in mice? The only paper I have found is Keshavarzi 2022. My impression from talking to people is that NP is too heavy for freely moving mice (except possibly if you select only males and put them through a neck-strengthening exercise routine)
Matteo Carandini@chrisXrodgers @seeingwithsound @kevinbolding Hi yes Neuropixels probes can do chronic recordings in freely moving mice, including females, if the implant is light enough. For an overview of available implants see here: https://youtu.be/_M5Uz8KZ6WQ Our lab has developed a particularly light one called "Apollo". It is being used by 20+ labs. Preprint should be on bioRxiv tomorrow or in the next couple of days.
