@_lennart
The first thing that comes to mind when file writes are slow is that you have a failing drive, or perhaps an older SSD which is behaving badly and in need of a TRIM. It's reasonable for read performance to be fine if the problem is with writing.
Slow drawing of GUI elements suggests that there's a performance bottleneck somewhere -- If you are having I/O troubles then that could be a side effect, but it may also be something completely unrelated.
The whole thing may just be a graphical problem which is slowing down everything else. Disabling the GUI entirely and switching to a text VT to retest may at least give you a direction to look in.
I would start by taking another look at your top / iostat /sar / or whatever report. You already mentioned that memory and CPU are good, but if you are seeing high IOWait times then that would point to a problem even if the read/s and write/s are low. If you have it configured, "sar" can give you detailed reports going as far back for days or weeks, which is helpful for problems which won't stand still when you want them to. The "dmesg" output should include any warnings thrown by the kernel over non-responsive devices or processes, so that's always worth checking on.
Another option is thermal problems. If anything is overheating that could easily lead to throttling which would look (correctly) like a massive slowdown of the entire system. "sensors" may give you some helpful input there if it has been configured, and if nothing else works you should be able to see all of your internal temperatures through BIOS.
Whatever it is, good luck.