I've been running Linux for 15 years and am stuck. Help!

On Ubuntu Desktop, sometimes (usually after a few minutes - sometimes not at all until reboot) all file write operations seem to hang, while opening files is not a problem. Can't kill processes, they just go <defunct>. Extremely slow drawing of windows.

What's going on here? Memory and CPU look good. Open files are not crazy... io load is very low. Not virtualized.

Any ideas?

@_lennart Knee-jerk reaction is the disk is going bad. It wouldn't hurt to do a backup as soon as you can and then run a disk check and/or inspect the SMART values.
@_lennart P.S. I've had disks go bad even when the SMART report didn't show anything unusual. It just died suddenly after a slow bout of degradation. It was somewhat similar to what's being reported here.