The "molecular athlete" is now out in the final form! Available #openaccess in Physiological Reviews (see link below).
Great collaboration with Regula Furrer of our very own lab @biozentrum @unibasel_en and John A. Hawley of the Australian Catholic University in Melbourne, Australia.
What to expect (a short thread):
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https://doi.org/10.1152/physrev.00017.2022
#exercise #muscle #myomastodon #ScienceMastodon #athlete #endurancetraining #resistancetraining #skeletalmuscle
The review covers topics from molecules to medals, endurance and resistance training, with a focus on human biology wherever possible, and provides references for more in-depth reading.
Part I: evolutionary perspectives of human performance, and the "hallmarks of athletes".
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Part II: Training principles, strategies and paradigms, with intensity vs. volume, altitude/hypoxic, low glycogen, and circadian training as examples, including a discussion of the scientific evidence for performance enhancement.
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Part III: Physiological, morphological, cellular and functional adaptations to exercise training. Includes oxygen provisioning and usage, neural and neuromuscular changes, hypertrophy, fiber types, energy metabolism (incl. mitochondria) and muscle memory/epigenetics.
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Part IV: The molecular mechanisms of muscle plasticity in exercise. Discussed in different phases: from anticipation to initiation and activity, cessation/fatigue/exhaustion, repair and regeneration, including crosstalk with the molecular clock/circadian rhythms.
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Part V: Can we all become gold medalists? Individual differences/(non-)responders (?), exercise genetics, exercise in aging/Master athletes, and a look ahead (including the use of wearables and -omics).
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Part VI: Conclusion and perspectives. The future of exercise sciences should span from molecular biology to human exercise physiology, extend to athletes and coaches, and to clinicians. Insights are central for human health, and should be applied in prevention and treatment.
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The "Molecular Athlete" is hopefully of use to a broad readership, from student to specialist, from molecular to applied researcher. Thanks to
@snsf_ch @ERC_Research and others that kept our labs running while we invested a lot of time in this opus.
https://doi.org/10.1152/physrev.00017.2022
BTW, I am not sure whether I do these threads on @Mastodon correctly... (apparently not according to @doctorow => https://doctorow.medium.com/how-to-make-the-least-worst-mastodon-threads-daa33943ac31 ).
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How do our #muscles adapt to #training? What is the difference between the changes elicited by #endurancetraining and #resistancetraining? Which types of training actually work? What defines elite #athletes? Can we all become gold medalists? How is #exercise performance affected by #aging, and how d
Christoph Handschin