Oliver ZettinigNov 24, 2022
Eric Topol
Just published
@ScienceMagazine

A universal influenza mRNA vaccine effective against all 20 lineages of influenza A and B, protective in experimental models
https://www.science.org/doi/10.1126/science.abm0271
Nov 24, 2022 at 7:27pmWeb
Show threadLucas NivonNov 24, 2022
@erictopol I’m very curious to see a comparison with other universal flu efforts from JnJ (Cyrus collaboration), NIH and others. https://www.sandiegouniontribune.com/business/biotech/sdut-universal-flu-vaccine-research-scripps-janssen-2015aug24-story.html
Universal flu vaccine a step closer

Progress toward a universal flu vaccine is described in two independent animal studies published Monday, in Science and Nature Medicine.

San Diego Union-Tribune
Show threadraw937Nov 24, 2022
@erictopol wow!! Sign me up!!
Show threadbkNov 24, 2022
@erictopol #thankful for mRNA vaccines!
Show threadAlan CardNov 24, 2022
@erictopol If it pans out in humans, this will warrant a whole other thanksgiving!
Show threadJyoti MishraNov 24, 2022

@erictopol I just checked this with my mate who's a virology researcher and she says, yup, could be amazing!

#virology #influenza #mrna

Show threadSue StoneNov 24, 2022
@erictopol now that is worth a big shout!
Show threadAwithonelisonNov 24, 2022
@erictopol
I can hardly wait!
Show threadNeil PhDNov 24, 2022
@erictopol
Is not the subtype that's the problem the majority of the time, as antigenic shifts are relatively rare, it's the antigenic drift which will still need to be addressed.....
Show threadHenryHill1Nov 24, 2022
@erictopol Mind blown. One Stop Shopping.
Show threadZubairNov 24, 2022
@erictopol Growing up, I watched Start Trek and it always fascinated me how they could come up with a vaccine so quickly. So when the mRNA vaccine came out, I wanted the latest technology and thought of Star Trek. On its own, the whole concept of mRNA is a leap forward.
Show threadJaddyNov 25, 2022

@zubair

the shame ist: The technology is over 20 years old, but no one wanted to finance necessary clinical studies.

Many scientists and start-ups like BioNTech tried to get VC, but old-fashioned vaccine production was too profitable.

@erictopol

Show threadMureniusNov 25, 2022
@jaddy @zubair @erictopol Yay, capitalism 🙄
Show threadtom4okstateNov 25, 2022
@erictopol this concept has been talked about for years. I didn't think I'd live to see the day. So amazing.
Show threadLilly EvansNov 25, 2022
@erictopol wow! That is fantastic. Especially for someone like myself who could not have any flu vaccine since 1971 when I had penicillin anaphylactic shock after getting Hong Kong flu vaccine.
Show threadWes St. GreyNov 25, 2022
@dexamfetamine
Show threadTodd MxyzptlkNov 25, 2022
@erictopol excellent
Show threadJeremy JayNov 25, 2022
@erictopol as someone who’s whole household is recovering from the flu right now, this cannot come soon enough!
Show threadwas B (this is my old account)Nov 25, 2022
@erictopol wow wow wow, this sounds exciting!!
Show threadSimonellaNov 25, 2022
@erictopol
That is great news! I have enjoyed learning about mRNA vaccines and the potent protection they provide
Show threadAndreas Andersen 🇩🇰Nov 25, 2022
@erictopol interesting to see the effect og humans on hospitalization and mortality and how long the effect will last
Show threadAnya StickneyNov 25, 2022
@erictopol that’s great! Was it sponsored by Moderna or Physer?
Show threadLars Marowsky-Brée 😷Nov 25, 2022
@erictopol ohhh I want it
Show threadPetr DenisovNov 25, 2022
@erictopol I’m just curious, that is another one or the one?
Show threadKatyNov 25, 2022
@erictopol exciting to see how human trials go. I sometimes wonder how much impact the years where the wrong strain was selected (and thus lots of more severe flu even in vax'd) has contributed to vaccine uptake reluctance.
Show threadIngo FrickeNov 25, 2022
@erictopol To my understanding this vaccine is administered parenterally as all the other flu vaccines. Wouldn't a nasal application be way more effective also with respect to contain transmission?
In the strict sense the authors "just" demonstrated protection against H1N1 in the challenge model not all 20 strains
Show threadZollNov 25, 2022
@erictopol
Show threadDr. Russell PierceNov 25, 2022

@Dan1976 @erictopol that the majority of COVID anything is among the vaccinated in isolation is meaningless.

In other news... the majority of people are in the majority.

Show threadMiguel Narciso VianaNov 25, 2022
@erictopol wow. Scrolling through replies sure is diferent from the trash I use to see in the bird app
Show threadJedediah AmmondNov 25, 2022
@erictopol Next up common cold?
Show threadJim McGuireNov 25, 2022

@erictopol

Thanks, Eric! I expect lots of other great outcomes of the mRNA technology.

Show threadLarsNygardNov 25, 2022

@erictopol

Interesting approach with throwing all the antigens we know of in one mRNA vaccine.

However I'm a bit sceptical to how this will work out when moving from animal models to humans. Sounds like it could be a little unpredictable?

It's totally different from the HA-stem protein approach or the FI6 antibody.

Speaking of FI6, haven't heard about that for a long time. Guessing it's not viable to be engineered with mRNA?

Show threadSilentwolfNov 28, 2022

@erictopol

I have vaccinations against covid-19. It does work!!!