Sparrow/Liz

This is interesting! I had been wondering about B5 from a #LongCovid angle, specifically wrt "Covid toes"

I found some WWII-era and earlier studies linking B5 deficiency with similar symptoms to COVID toes. (NB research methodology is... lacking)

Using names such as:
#Erythromelalgia tropicans
Hot foot and hand disease
Nutritional melalgia

I'm wondering if perhaps COVID or Long COVID affect how the body processes B5 🤔

#NEISvoid

https://openbiblio.social/@HWiesenmueller/109369732888823734

Heidrun WiesenmĂĽller (@[email protected])

Study on #Covid and #VitaminB (accepted paper) Darand, M., Hassanizadeh, S., Martami, F., Shams-rad, S., Mirzaei, M., & Hosseinzadeh, M. (2022). The association between B vitamins and the risk of #COVID-19. British Journal of Nutrition, 1-26. https://doi.org/10.1017/S0007114522003075 "A higher intake of vitamin #B5 could reduce the odds of COVID-19 by 47%, and a moderate intake of vitamin #B12 had a protective effect on COVID-19. Although our study has promising results, stronger clinical studies are needed."

OpenBiblio.Social
Nov 19, 2022 at 2:42pmWeb
Show threadSparrow/LizNov 19, 2022

Via the linked post (still figuring out how QTs work on here)

https://doi.org/10.1017/S0007114522003075​

"A higher intake of vitamin B5 could reduce the odds of COVID-19 by 47%, and a moderate intake of vitamin B12  had a protective effect on COVID-19. Although our study has promising results, stronger clinical studies are needed."

The association between B vitamins and the risk of COVID-19 | British Journal of Nutrition | Cambridge Core

The association between B vitamins and the risk of COVID-19

Cambridge Core
Show threadSparrow/LizNov 19, 2022

From what I understand, nutritional deficiencies can happen through several mechanisms:

1. Not consuming enough

2. Your body not absorbing enough (common with gut issues like Crohn's, celiac, etc; also depends on digestive enzymes, gut motility, et al)

3. Your body using a lot of a particular nutrient (eg, if you're in the heat, your body uses more water and electrolytes)

I wonder if acute and/or Long Covid affects how your body uses B5

Show threadSparrow/LizNov 19, 2022

Anyway, we don't actually have a lot of data about Vitamin B5 deficiencies

Because it usually occurs in combo with other deficiencies, so it's hard to isolate which symptoms specifically are due to vitamin B5 deficiency

There are some studies on B5 deficiency from WWII and earlier, but they're mostly:

- case studies from colonized famine areas written by the British
- ethical nightmares where they induced B5 deficiency in people

Show threadSparrow/LizNov 19, 2022

This is the "let's see what happens if we intentionally induce B5 deficiencies" and is done on...6 people (3 of whom were "controls")

So it's really hard to extrapolate useful data from this

https://www.jci.org/articles/view/103756

Based on this (terrible) study, B5 deficiency seems to cause

Burning hands and feet
"A peculiar gait"
Increased sensitivity to insulin
Fatigue
Irritability
Headaches
Muscle cramps

JCI - Pantothenic Acid Deficiency in Man

Show threadSparrow/LizNov 19, 2022

There's a fairly recent and comprehensive European consensus guideline on nutritional deficiencies/inadequacies

"ESPEN micronutrient guideline." Clinical Nutrition 41 (2022) 1357e1424

Available here as a PDF download
https://doi.org/10.1016/S0261-5614(22)00166-2

And from what I can tell, they haven't found any more recent studies on B5 deficiency because no one has figured out an ethical way to study it

#Nutrition
#B5
#NEISvoid