Aris KatzourakisI am particularly vexed by the continued usage of #ImmunityDebt. It is not an established concept, and has never been used prior to the pandemic. And it mixes and matches a) population immunity, which is trivially true, b) individual severity effects, which are not, c) has echoes of the still controversial 'hygiene hypothesis', and d) uses a loaded colloquialism - 'debt' - to whom, and why? Would much prefer we stuck to precise terminology.
Nick Loman@ariskatzourakis Ooh, we can probably have conversations over here like this safely!? I agree, it doesn't make much sense at all. What do you make of all this stuff about COVID-19 immune system impairment as the "alternative" hypothesis? I think the very real post-COVID healthcare system effects might explain most observations.
@pathogenomenick This is the hope-that we can have conversations about topics like this, without, for example, being quote-tweeted by a hypothetical account with over 100,000 followers that likes controversy, and enjoys setting their followers and bots on the tweeter. Though its worth not naming such hypothetical examples because if you say their name three times they open a Mastodon account.
@pathogenomenick as for the alternate hypothesis, I think its plausible to suggest that the after effects of covid in rare cases can contribute to pathology of subsequent infection. And because of sheer numbers, 'rare' things appear often. But like you say-healthcare system effects are very real and certainly matter.
Willem van Schaik@ariskatzourakis @pathogenomenick too late, it has already happened allegedly
J.H.Noyes@pathogenomenick @ariskatzourakis
IMO, nothing settles arguments like pathology. The following is a link to a panel hosted by the lead author of the NIH study SARS-CoV-2 Infection and Persistence Throughout the Human Body and Brain. Discussion begins at 33:50 and can be followed reasonably well without viewing the first half of the video, though it is certainly there if you want it:
SARS-CoV-2 Infection and Persistence Throughout the Human Body and Brain
This will be an NIH–FDA COVID-19 SIG lecture concerning findings from the NIH COVID-19 Autopsy Consortium. Daniel Chertow is a tenure-track investigator in the Critical Care Medicine Department at the NIH Clinical Center and in the Laboratory of Immunoregulation at the National Institute of Allergy and Infectious Diseases.<br><br>For more information go to <a href="https://www.niaid.nih.gov/research/covid-19-sig-lecture-series">https://www.niaid.nih.gov/research/covid-19-sig-lecture-series</a>