"A new Science study shows that mammals had begun to change and diverge even before the Earth was hit by the asteroid that killed the dinosaurs, approximately 65 million years ago. scim.ag/2BP #Zoonomia"

https://twitter.com/sciencemagazine/status/1657377684924645377?s=12&t=E9vIjKnGSUcpmW93NHUTYw

Science Magazine on Twitter

“A new Science study shows that mammals had begun to change and diverge even before the Earth was hit by the asteroid that killed the dinosaurs, approximately 65 million years ago. https://t.co/Icl7K0dygV #Zoonomia”

Twitter
Scientists Sequenced #DNA of Nearly Every #Mammal on Earth in Unprecedented Project
The most ambitious #genetics project to date dives into the #genes of nearly every living mammal for insight into life itself.
#Zoonomia researchers identified more than 100 million sections of #genomes that are barely different across the 200-plus #species. They think these areas are the ones that are crucial for the biology that makes all animals tick
https://www.vice.com/en/article/4a3wwg/scientists-sequenced-dna-of-nearly-every-mammal-on-earth-in-unprecedented-project
Scientists Sequenced DNA of Nearly Every Mammal on Earth in Unprecedented Project

The most ambitious genetics project to date dives into the genes of nearly every living mammal, including humans, for insight into life itself.

#Zoonomia paper Christmas et al 2023 reports genes TLK1 and HAT1 interact in cerebral cortex with a conserved non coding region, and "both are expressed in the cerebral cortex of 19 (TLK1) or 21 (HAT1) out of 19 or 21 mammals analyzed in a previous study, respectively (87)." How do they know? They used precomputed expression calls with comparison of homolog organs and ortholog genes in @bgeedb's Expression Comparison tool 🤓. https://www.science.org/doi/10.1126/science.abn3943#body-ref-R87 #GeneExpression #evodevo
#zoonomia - the power of comparative genomics to understand basic biology, biodiversity and human health at its best!
My fav findings are:
- lessons from hibernators on longevity
- use of genomes to design conservation programs
- detailed timeline for mammal evolution
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RT @eenork
Brown bears hibernate through the whole winter, hardly moving at all. They don't get blood clots and strokes.
Humans? We have to stretch during flights.
https:…
https://twitter.com/eenork/status/1651813425947787270
Elinor Karlsson on Twitter

“Brown bears hibernate through the whole winter, hardly moving at all. They don't get blood clots and strokes. Humans? We have to stretch during flights. https://t.co/wxK5IhaF6j @JoBMller @V_Ehreiser @AnneDueck @FrobertOle @petzold_tobias #Zoonomia”

Twitter
Researchers use genomes of 241 species to redefine mammalian tree of life

Research led by a team of scientists from the Texas A&M School of Veterinary Medicine and Biomedical Sciences puts to bed the heated scientific debate regarding the history of mammal diversification as it relates to the extinction of the non-avian dinosaurs. Their work provides a definitive answer to the evolutionary timeline of mammals throughout the last 100 million years.

Phys.org

I inevitably end up telling my students on several occasions in class how we're such a "narcissistic species"... So glad to see this #Zoonomia project published!
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RT @eenork
Humans can be... well... a little self-absorbed... our DNA is the MOST SEQUENCED DNA EVER!

SO. MUCH. DATA.

But are we sooooo special?!? #Zoonomia 1/n
https://twitter.com/eenork/status/1651813414673448968

Elinor Karlsson on Twitter

“Humans can be... well... a little self-absorbed... our DNA is the MOST SEQUENCED DNA EVER! SO. MUCH. DATA. But are we sooooo special?!? #Zoonomia 1/n”

Twitter
Zoonomia Project: A Genomic Odyssey Across 240 Mammalian Species Explains Human Disease Risks and More

The international Zoonomia Project has analyzed the genomes of 240 mammalian species, revealing conserved regions that could be biologically essential and may influence diseases. It suggests 10% of the human genome is functional, extending beyond protein-coding areas. The research has uncovered gene

SciTechDaily