We hosted the amazing
#Efrat #Shema from
#weizmannscience at the
#Ludwig Institute in
#Oxford today. Amazing work on single-molecule
#epigenetics for
#cancer early detection, but also really insightful basic
#biology. Shows that it pays to think about the _function_ of your biomarkers. Anyway, check out her work, it's very impressive:
https://www.weizmann.ac.il/dept/irb/Shema/Home
We study how epigenetic deregulation in cancer contributes to tumor initiation and progression. To address these fundamental questions, we develop and apply innovative cutting-edge single-molecule and single-cell technologies. The activity of genes and regulatory elements is modulated by their cell type-specific chromatin organization. Histone modifications and chromatin regulators play important roles in cellular differentiation and development.
Efrat Shema's LabCel-lctiv: New in vivo #proximity #biotin labelling approach by Maya Schuldiner lab #WeizmannScience allows study of stable and transient #protein-protein interactions, such as substrate specificity comparison between homologous #yeast #translocons #Sec61 and #Ssh1
https://www.embopress.org/doi/10.15252/embj.2022113385