We hosted the amazing #Efrat #Shema from #weizmannscience at the #Ludwig Institute in #Oxford today. Amazing work on single-molecule #epigenetics for #cancer early detection, but also really insightful basic #biology. Shows that it pays to think about the _function_ of your biomarkers. Anyway, check out her work, it's very impressive: https://www.weizmann.ac.il/dept/irb/Shema/
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We study how epigenetic deregulation in cancer contributes to tumor initiation and progression. To address these fundamental questions, we develop and apply innovative cutting-edge single-molecule and single-cell technologies. The activity of genes and regulatory elements is modulated by their cell type-specific chromatin organization. Histone modifications and chromatin regulators play important roles in cellular differentiation and development.

Efrat Shema's Lab

Cel-lctiv: New in vivo #proximity #biotin labelling approach by Maya Schuldiner lab #WeizmannScience allows study of stable and transient #protein-protein interactions, such as substrate specificity comparison between homologous #yeast #translocons #Sec61 and #Ssh1

https://www.embopress.org/doi/10.15252/embj.2022113385