PLOS BiologyPrevious #cryoEM of #synucleinopathy α-synuclein fibrils revealed a ‘mystery density’ at the protofilament core. @jakob_lab &co now show that it's #polyphosphate, which binds a lysine-rich pocket & helps stabilize the fiber #ParkinsonsDisease #PLOSBiology https://plos.io/3YP7Gdf
Amyloid accelerator polyphosphate fits as the mystery density in α-synuclein fibrils
Previous cryo-EM structures of synucleinopathy patient-derived α-synuclein fibrils revealed a ‘mystery density’ at the core of the protofilaments. This study identifies polyphosphate as this density, which binds a lysine-rich pocket and contributes to fiber stabilization.
Victoria Stuart 🇨🇦 🏳️⚧️