Frederic BlancMay 1

#lewybodies Normative gene expression may partially contribute to regional brain atrophy in Dementia with Lewy bodies.

https://www.nature.com/articles/s41531-026-01355-2

Regional gene expression and brain atrophy in dementia with Lewy bodies: an imaging transcriptomics study - npj Parkinson's Disease

Regional brain atrophy has been observed in dementia with Lewy bodies (DLB), yet determinants of regional vulnerability remain unclear. Using imaging transcriptomics, we examined whether normative gene expression patterns relate to regional atrophy in DLB. We included 164 DLB patients (49 women) and 164 age- and sex-matched healthy controls from three European centres and the Mayo Clinic, USA. Volumetric atrophy was quantified from T1-weighted MRI across 58 left-hemispheric regions using w-scores. Normative expression of twelve genes implicated in alpha-synuclein, beta-amyloid, and tau pathology was extracted from the Allen Human Brain Atlas. DLB patients showed diffuse atrophy across most regions. In the full cohort, normative expression of MAPT, PINK1, and PSEN2 predicted regional atrophy after correction for spatial autocorrelation, although none survived multiple-testing correction. In the Mayo Clinic sub-cohort, expression of APP, BIN1, GBA, MAPT, PINK1, SNCA, and TMEM175 significantly predicted atrophy and survived multiple-testing correction. Random forest models did not outperform spatial null models in the full cohort, but PARK7, PINK1, and PSEN2 consistently emerged as important predictors. A significant global model was observed in the Mayo Clinic sub-cohort, driven by GBA, LRP1, and PINK1. These findings suggest that normative gene expression partially contributes to regional brain atrophy in DLB.

Nature
Frederic BlancMar 15
Isolated RBD: Decrease inflammation in prodromal dementia with #Lewybodies and increase in #Parkinson's disease.
https://movementdisorders.onlinelibrary.wiley.com/doi/10.1002/mds.70265
ErikBussink Dec 31
On this day last day of the year, I remember the passing of my dad, a year ago, he did not get to see the dumpster fire that was 2025.
He suffered of #LewyBodies (Dementia) and we got lucky he still remembered us till the last days.
(((Cindy Weinstein)))Dec 25, 2023
Thank you, dear reader, for this incredibly kind review of #FindingtheRightWords, the #memoir I wrote with #neurologist, #Dr.BruceMiller. #Dementia doesn't take a break for the holidays, which means #caregivers don't get a break either. Sending strength to those of you who are living with #Alzheimer's, caring for someone with it or another form of dementia (#FTD, #CTE, #vascular, #LewyBodies, #early-onset, #Creutzfelt-Jakob, and others), and/or loving someone with #dementia.
(((Cindy Weinstein)))Dec 22, 2023

https://www.washingtonpost.com/opinions/2023/12/22/nursing-home-care-dementia/

2020: 7 million in the US w/#dementia
2040: estimate of ~12 million in the US w/dementia

Dementia is the umbrella term. The "other diseases" include #FTD (FrontoTemporalDementia), #CTE (repeated concussions), #VascularDementia, #LewyBodies, Creutzfeldt-Jakob, #Alzheimer's, #early-onset Alzheimer's & more.

Let's revisit (& pass) #Biden's plan to support financially #caregivers, who often die before the person w/dementia for whom they are caring. Then what?

#EndAlz

The dementia crisis is here. Better training can’t wait.

As more and more elderly Americans with dementia reside in assisted-living homes, states need to make sure they receive high-quality care.

The Washington Post
(((Cindy Weinstein)))Dec 22, 2023

https://www.washingtonpost.com/opinions/2023/12/22/nursing-home-care-dementia/

2020: 7 million in the US w/#dementia
2040: estimate of ~12 million in the US w/dementia

Dementia is the umbrella term. The "other diseases" include #FTD (FrontoTemporalDementia), #CTE (repeated concussions), #VascularDementia, #LewyBodies, Creutzfeldt-Jakob, #Alzheimer's, #early-onset Alzheimer's & more.

Let's revisit (& pass) #Biden's plan to support financially #caregivers, who often die before the person w/dementia for whom they are caring. Then what?

#EndAlz

The dementia crisis is here. Better training can’t wait.

As more and more elderly Americans with dementia reside in assisted-living homes, states need to make sure they receive high-quality care.

The Washington Post
Show threadVictoria Stuart 🇨🇦 🏳️‍⚧️Jul 16, 2023

... cont'd 14/14 [scroll/page up for prev. content]

Related hashtags for this Long COVID discussion

#COVID19 #COVID #SARScov2 #LongCOVID #1918flu #PublicHealth #pandemics #LongFlu #SpanishFlu #PAIS #PostAcuteInfectionSyndrome #RiskAvoidance #RiskAversion #EllsbergParadox #amyloids #neurobiology #LewyBody #LewyBodies #neurodegradation #CellBiology #ParkinsonsDisease #parkinsonism #ProteinMisfolding #alphaSynuclein #synucleinopathy #synucleinopathies #DreamEnactmentSleepDisorder #SleepDisorders

Show thread(((Cindy Weinstein)))Jul 4, 2023
@thundergod97 @abejaclaustro @nathanlovestrees @cobalt. Absolutely #EndDementia -- all of them, #LewyBodies, #VascularDementia, #FTD, #CTE. I am so sorry about your father. Sending strength.
Show threadStephenCApr 25, 2023
@DrPsyBuffy it is definitely unfortunate that #lewybodies can only be confirmed by autopsy #LomgCovid
Phys.orgMar 1, 2023

Referenced link: https://medicalxpress.com/news/2023-03-intestinal-bacteria-dementia-lewy-bodies.html
Discuss on https://discu.eu/q/https://medicalxpress.com/news/2023-03-intestinal-bacteria-dementia-lewy-bodies.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/medical_xpress/status/1630986344494243841#m

RT by @physorg_com: Researchers identify three #intestinalbacteria found in dementia with #Lewybodies @NagoyaUniv_info https://www.nature.com/articles/s41531-022-00428-2 https://medicalxpress.com/news/2023-03-intestinal-bacteria-dementia-lewy-bodies.html

Researchers identify three intestinal bacteria found in dementia with Lewy bodies

Dementia with Lewy bodies (DLB), one of the most common forms of dementia, has no cure. Previous studies suggested that gut bacteria, the microorganisms that live in the human digestive tract, play a role in Parkinson's disease, another neurodegenerative disorder, but the bacteria involved in DLB had not been identified. Now, a group led by researchers at the Nagoya University Graduate School of Medicine in Japan has identified three bacteria involved in DLB—Collinsella, Ruminococcus, and Bifidobacterium. Their findings, reported in npj Parkinson's Disease, suggest new avenues for diagnosis and treatment.

Medical Xpress