PLOS BiologyApr 13
#Sphingosine -1-phosphate receptors #S1PRs play complex roles in several pathological processes. #CryoEM structures of four agonist-bound S1PR1-Gi1 complexes reveal the structural determinants underlying agonist selectivity among different subtypes @PLOSBiology https://plos.io/4co0A4W
Scientific FrontlineJan 25
Researchers have identified #sphingosine kinase 1 as a critical #enzyme that drives the excess growth of smooth muscle cells, a primary cause of life-threatening #arterial blockages in patients with #Williams-Beuren syndrome.
#Medical #Genetics #Biology #sflorg
https://www.sflorg.com/2026/01/med01252601.html
Researchers Uncover Potential Pathway To Address Williams-Beuren Syndrome

Williams-Beuren syndrome is a rare, congenital disease in which the main morbidity and mortality comes from obstructions