Krzysztof SakrejdaTo survive, #Chemistry departments must place a statue of #LouisFieser in the front lobby and all grants must address the #DepartmentOfWar priorities on maximizing Geneva convention violations. #SmallMolecule chemistry is banned and #NSF will only fund #YugeMoleculeChemistry, may the biggest molecule win.
Vivek Mutalik2017 paper, A dynamic map for learning, communicating, navigating and improving therapeutic development
#smallmolecule #drugdevelopment
Marco RadiAn interesting point on #drugdiscovery
“.... How do we truly define a #smallmolecule #drug today? ... Are #chemists making the “wrong” kinds of molecules?
Or have we entered a new era of drug modalities?
.... And just to prove chemists can continue to make the “right” kinds of molecules, here are some recent low Mw drug #approvals -
- Tecfidera (Mw 144), #FDA approved 2013
- Tavaborole (Mw 151), FDA approved 2014
- Avibactam (Mw 265), FDA approved 2015
- Benznidazole (Mw 260), FDA approved 2017
- Migalastat (Mw 163), FDA approved 2018
How many novel small molecule drugs Mw<300 are yet to be discovered?”
