The EMBO JournalJul 24, 2024
CMG #helicase disassembly is essential and driven by two pathways in budding yeast
Karim Labib and colleagues show that Pif1-family helicases mediate an ancestral pathway for ‘old’ #replisome disassembly during the subsequent S-phase
https://www.embopress.org/doi/full/10.1038/s44318-024-00161-x
CellBioNewsMar 29, 2024

Scientists discover a key quality-control mechanism in #DNA #replication.

#55LCC #replication_complex #replisome

https://phys.org/news/2024-03-scientists-key-quality-mechanism-dna.html

Scientists discover a key quality-control mechanism in DNA replication

When cells in the human body divide, they must first make accurate copies of their DNA. The DNA replication exercise is one of the most important processes in all living organisms and is fraught with risks of mutation, which can lead to cell death or cancer.

Phys.org
The EMBO JournalOct 2, 2023
How do physiological DNA secondary structures affect genome stability?
In vitro reconstitution by Gideon Coster and coworkers at ICR London shows that a single physiological #G4 or iM #quadruplex formed during #replication stalls the eukaryotic #replisome by inhibiting leading strand synthesis
https://www.embopress.org/doi/full/10.15252/embj.2023114334