Giuseppe MichieliOct 1, 2024

Tetracistronic #minigenomes elucidate a functional promoter for #Ghana virus and unveils #Cedar virus #replicase promiscuity for all #henipaviruses

Source: Journal of Virology, ABSTRACTBatborne henipaviruses, such as Nipah and Hendra viruses, represent a major threat to global health due to their propensity for spillover, severe pathogenicity, and high mortality rate in human hosts. Coupled with the absence of approved vaccines or therapeutics, work with the…

https://etidioh.wordpress.com/2024/10/01/tetracistronic-minigenomes-elucidate-a-functional-promoter-for-ghana-virus-and-unveils-cedar-virus-replicase-promiscuity-for-all-henipaviruses/

Tetracistronic #minigenomes elucidate a functional promoter for #Ghana virus and unveils #Cedar virus #replicase promiscuity for all #henipaviruses

Source: Journal of Virology, ABSTRACTBatborne henipaviruses, such as Nipah and Hendra viruses, represent a major threat to global health due to their propensity for spillover, severe pathogenicity,…

ETIDIoH
Matt WillemsenJan 25, 2024
Chilling Discovery: Cryo-EM Uncovers Ancient Molecular Machine of Life
https://scitechdaily.com/chilling-discovery-cryo-em-uncovers-ancient-molecular-machine-of-life/ #CryoEM #RNA #replicase #Biochemistry #Evolution
Chilling Discovery: Cryo-EM Uncovers Ancient Molecular Machine of Life

RNA is thought to have sparked the origin of life by self-copying. Researchers from Aarhus University, Denmark, and MRC LMB Cambridge, England, have revealed the atomic structure of an "RNA copy machine" through cryo-EM. This breakthrough sheds light on a primordial RNA world and fuels advancements

SciTechDaily
Giuseppe MichieliFeb 1, 2023
Structural basis for #substrate #selection by the #SARS-CoV-2 #replicase https://www.nature.com/articles/s41586-022-05664-3
Structural basis for substrate selection by the SARS-CoV-2 replicase - Nature

Cryo-EM is used to visualize the SARS-CoV-2 RTC bound to each of the natural NTPs as well as remdesivir triphosphate (RDV-TP) in states poised for incorporation, explaining the interactions required for NTP recognition and RDV-TP selectivity.

Nature