Patrick van der WelFeb 17
End of a busy day of PhD defenses. Congratulations to Dr Raffaella Parlato from my lab! And also to Dr Vasista Adupa from the Onck lab! Two #polyQ containing theses and defenses. :-)
Show threadPatrick van der WelJul 31, 2025
Online: doi.org/10.1002/chem... “Probing How Anti-huntingtin Antibodies Bind the Fibrillar Fuzzy Coat Using Solid-State #NMR” - continuing our research on #huntingtonsdisease and in particular the aggregated #polyQ proteins involved. Here we looked at antibodies binding to the latter. #nmrchat

Probing How Anti‐huntingtin An...
Patrick van der WelSep 6, 2024
Looking forward to the European #huntingtonsdisease network ( #EHDN) meeting next week, in beautiful Strasbourg (https://ehdn.org/ehdn2024/ ). It looks like a great line-up of speakers and topics, and offers a chance to catch up with fellow HD researchers (and collaborators). Are you there too? #polyQ
EHDN 2024 – European Huntington's Disease Network

Patrick van der WelApr 2, 2024
Our latest (review) article is now available online: https://doi.org/10.1042/BST20230731 in the journal Biochemical Transactions. In this invited article “Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation”, I have reviewed the contributions that solid-state #NMR #SSNMR has made to our understanding of the mutant protein aggregates in #huntingtonsdisease and related #polyQ disorders. (1/2)
Solid-state nuclear magnetic resonance in the structural study of polyglutamine aggregation

The aggregation of proteins into amyloid-like fibrils is seen in many neurodegenerative diseases. Recent years have seen much progress in our understanding of these misfolded protein inclusions, thanks to advances in techniques such as solid-state nuclear magnetic resonance (ssNMR) spectroscopy and cryogenic electron microscopy (cryo-EM). However, multiple repeat-expansion-related disorders have presented special challenges to structural elucidation. This review discusses the special role of ssNMR analysis in the study of protein aggregates associated with CAG repeat expansion disorders. In these diseases, the misfolding and aggregation affect mutant proteins with expanded polyglutamine segments. The most common disorder, Huntington's disease (HD), is connected to the mutation of the huntingtin protein. Since the discovery of the genetic causes for HD in the 1990s, steady progress in our understanding of the role of protein aggregation has depended on the integrative and interdisciplinary use of multiple types of structural techniques. The heterogeneous and dynamic features of polyQ protein fibrils, and in particular those formed by huntingtin N-terminal fragments, have made these aggregates into challenging targets for structural analysis. ssNMR has offered unique insights into many aspects of these amyloid-like aggregates. These include the atomic-level structure of the polyglutamine core, but also measurements of dynamics and solvent accessibility of the non-core flanking domains of these fibrils' fuzzy coats. The obtained structural insights shed new light on pathogenic mechanisms behind this and other protein misfolding diseases.

Portland Press
Patrick van der WelJan 16, 2024

Yay! It is now online: our latest paper on the use #NMR spectroscopy to look at #amyloid formation by #polyQ peptides outfitted with a backbone modification, which allows photochemical control over beta-hairpin formation. Together with the groups of Szymanski and Feringa in #Groningen. A great new tool for studies of #amyloid formation mechanisms.

https://pubs.acs.org/doi/10.1021/jacs.3c11155
#photochemistry #NMR #huntingtonsdisease #amyloid

Patrick van der WelSep 27, 2023
Sign up now! HDF Foundation webinar about the protein that is mutated in #huntingtonsdisease. Presented by J. Frydman and N. Barbosa from Stanford University - happening tomorrow!! https://www.hdfoundation.org/webinars #polyQ #amyloid #biophysics
HDF Webinars — Hereditary Disease Foundation

Hereditary Disease Foundation
P.C.A. van der WelSep 18, 2023
Op 28 September organiseert de #HDF stichting een interessante webinar over het eiwit dat de ziekte van #Huntington veroorzaakt. Voor meer informatie: https://www.hdfoundation.org/webinars Het is een presentatie door Judith Frydman en Natalia Barbosa, beiden van #Stanford Universiteit in de VS (en dus Engelstalig). #ziektevanhuntington #polyQ
HDF Webinars — Hereditary Disease Foundation

Hereditary Disease Foundation
Patrick van der WelSep 18, 2023
Interesting webinar about #HuntingtonsDisease is coming on Sept 28th 2023, via the #HDF foundation: https://www.hdfoundation.org/webinars
An online presentation by Judith Frydman and Natalia Barbosa (#Stanford) talking about “How expanding our knowledge of the Huntington's protein can unlock new therapies”. (A statement I fully agree with - to address a protein misfolding disease like HD, we need to understand what this #misfolding process really is!) #polyQ #huntingtondisease #biophysics
HDF Webinars — Hereditary Disease Foundation

Hereditary Disease Foundation
P.C.A. van der WelSep 7, 2023
Gezocht door collega’s in Amsterdam: postdoctoraal onderzoeker die meehelpt de Ziekte van #Huntington te onderzoeken. Meer info hier: https://werkenbij.amsterdamumc.org/en/vacatures/research/postdoc-huntington-and-ataxia-
#polyQ #ziektevanhuntington #onderzoek #biochemie #neuroscience
Vacatures - Postdoc Huntington and Ataxia - Amsterdam UMC

Postdoc: Improving selective degradation of mutant proteins in Huntington’s Disease

Amsterdam UMC
Patrick van der WelAug 23, 2023
Don’t miss the #iupacchains2023 parallel session 10 on Structural Biology and Protein Design at 10:20am - see the talk by my PhD student Raffaella Parlato! She will talk about our work with Wiktor Szymanski’s team (also University of #Groningen) - enabling #photochemical control over #polyQ #amyloid formation & structure. #ssNMR #chemistry