Cosmin SaveanuNew #paper! Structural and functional data from the Marc Graille lab, together with in vitro experiments from the Le Hir lab and our #yeast experiments, identified specific interactions between Upf1, the core #NMD RNA helicase and Nmd4, the yeast equivalent of SMG6 (the NMD #endonuclease in many organisms). Another surprising result showing how conserved NMD mechanisms are!
https://pubmed.ncbi.nlm.nih.gov/39331656/
https://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.3002821
Structure of the Nmd4-Upf1 complex supports conservation of the nonsense-mediated mRNA decay pathway between yeast and humans - PubMed
The nonsense-mediated mRNA decay (NMD) pathway clears eukaryotic cells of mRNAs containing premature termination codons (PTCs) or normal stop codons located in specific contexts. It therefore plays an important role in gene expression regulation. The precise molecular mechanism of the NMD pathway ha …