Leishmania genetic exchange is mediated by IgM natural antibodies - Nature

Genetic exchange of Leishmania parasites in the sand fly host is mediated by natural IgM antibodies, providing insights that will help generate reproducible and increased recovery of backcrosses for research purposes.

Nature

HOP1 and HAP2 are conserved components of the meiosis-related machinery required for successful #mating in #Leishmania

https://www.researchsquare.com/article/rs-3054842/v1

#meiosis #leishmaniasis #genome #genomics #mitosis #sexual #parasexual #fusion #cellfusion

HOP1 and HAP2 are conserved components of the meiosis-related machinery required for successful mating in Leishmania

Sexual recombination in Leishmania during development in the sand fly vector has been implicated based on Mendelian parental contributions observed in experimental hybrid genomes. Here, we performed functional analyses using in vitro and in vivo hybridization protoco...