Arjan BoltjesJun 23, 2023

"Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma"

Nice new work based on #scRNAseq from our Drost group colleagues at the #PrincessMaximaCenter. a.o., a potential role of #NECTIN3 and #TIGIT in #tumour-induced T cell dysfunction.
https://www.nature.com/articles/s41467-023-38886-8

#OpenAccess
#rhabdomyosarcoma
#immunology #ImmuneSuppression

Single-cell transcriptomics reveals immune suppression and cell states predictive of patient outcomes in rhabdomyosarcoma - Nature Communications

The cellular differentiation states of paediatric rhabdomyosarcoma (RMS) remain to be explored. Here, single-cell RNA sequencing analysis of RMS tumours reveals an immunosuppressive microenvironment and distinct transcriptional programs predictive of patient outcomes.

Nature
Ray MedinaNov 28, 2022
Is this evidence of the Leonardi effect rearing its head in a highly visited city? https://www.reviewjournal.com/local/local-las-vegas/some-of-nevadas-superbug-cases-found-at-2-las-vegas-hospitals-2682814/
#immunesuppression #leonardieffect
Some of Nevada’s ‘superbug’ cases found at 2 Las Vegas hospitals

<p>Higher cases numbers are concerning, though a facility where a case of Candida auris is identified may not be where the patient acquired the germ.</p>

Las Vegas Review-Journal