StructuralBiologyAug 20, 2024
Quantum-mechanical methods are used to more accurately identify the most likely proton­ation states of histidine rings #MacromolecularRefinement #Histidine #QuantumMechanicalPredictions https://t.co/ogeKchToZu
Protonation of histidine rings using quantum-mechanical methods

Histidine protonation is fraught, but a new quantum-mechanical method can provide insight into choices.

Acta Crystallographica Section D
CellBioNewsSep 23, 2023

Discovery of #histidine methylation as a new post-#translational modification of #histone proteins.

#DNA

https://phys.org/news/2023-09-discovery-histidine-methylation-post-translational-modification.html

Discovery of histidine methylation as a new post-translational modification of histone proteins

In eukaryotes, genomic DNA, which is a very long double helix containing all the genetic information, wraps around a globular protein called a histone and folds it many times before being contained within the nucleus.

Phys.org
Radek NowakDec 30, 2022
Great to see this out! EM12-SO2F engages #CRBN covalently in the IMiD pocket and can be used to efficiently block the #IMiD binding site. We share detailed methods for the synthesis and application #covalent #SuFx #histidine #TPD
Read more here: https://www.sciencedirect.com/science/article/pii/S0076687922003810?dgcid=author