jobRxivSep 19, 2024

Postdoctoral Position - Computational Biologist - Cancer Genomics

German Cancer Research Center

Postdoctoral position for a Computational Biologist to study #Genomics #genomicinstability #cancerheterogeneity #immunemicroenvironment in Cancer

See the full job description on jobRxiv: https://jobrxiv.org/job/german-cancer-research-center-27778-postdoctoral-...
https://jobrxiv.org/job/german-cancer-research-center-27778-postdoctoral-position-computational-biologist-cancer-genomics/?feed_id=82767

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Phys.orgJun 13, 2023

Referenced link: https://phys.org/news/2023-06-mechanisms-genomic-instability.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-06-mechanisms-genomic-instability.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1668624026229682178#m

Study identifies new mechanisms driving #genomicinstability @northwesternu https://rupress.org/jcb/article/222/8/e202208018/214139/The-Ndc80-Cdt1-Ska1-complex-is-a-central https://phys.org/news/2023-06-mechanisms-genomic-instability.html

Study identifies new mechanisms driving genomic instability

A recent Northwestern Medicine study published in the Journal of Cell Biology has identified new mechanisms that cause genomic or chromosomal instability during cell division, findings that may improve the development of biomarkers and targeted therapies for cancer.

Phys.org
Julien DelpierreNov 13, 2022
"[...] a tension-dependent signal on the #nucleus that sets the time for nuclear envelope permeabilization (NEP) and mitotic entry. This signal relies on #actomyosin #contractility, which unfolds the nucleus during the G2-M transition, activating the stretch-sensitive #cPLA2 on the nuclear envelope and regulating the nuclear translocation of #cyclin B1.[...]"
https://rupress.org/jcb/article-abstract/221/12/e202205051/213539/Nuclear-tension-controls-mitotic-entry-by
#BioMechanics #MechanoBiology #NuclearTension #CellBiology #CellCycle #CellDivision #NuclearEnvelope #NuclearTranslocation #CellCompression #GenomicInstability
Nuclear tension controls mitotic entry by regulating cyclin B1 nuclear translocation

Mitotic entry is regulated by the activity of cyclin B1-CDK1 complexes. In this study, Dantas et al. show that actomyosin-dependent nuclear tension during proph

Rockefeller University Press