Continuing our session on #genedrives, Dr. Laura Norris (Gates Foundation) shares insights into how scientists and policymakers can collaborate to shape the gene drive ecosystem for impact #WorldMalariaDay

Researchers develop #GeneDrives for plants: This would turn the environment itself into a laboratory. Once
released, there would be hardly any possibilities to interfere or control. Read more in our report:

https://www.testbiotech.org/en/news/gene-drives-for-plants-gamete-killers/

Gene Drives for plants: ‘gamete killers’ – Testbiotech

ForscherInnen entwickeln #GeneDrives für Pflanzen: Damit würde die Umwelt selbst zum Labor. Einmal freigesetzt, gäbe es kaum noch Eingriffs- und Kontrollmöglichkeiten. Mehr in unserer Meldung:

https://www.testbiotech.org/aktuelles/gene-drives-fuer-pflanzen-keimzellen-killer/

Gene Drives für Pflanzen: ‚Keimzellen-Killer‘ – Testbiotech

What should we call evolution driven by genetic engineering? Genetic welding, says researcher

With CRISPR-Cas9 technology, humans can now rapidly change the evolutionary course of animals or plants by inserting genes that can easily spread through entire populations. Evolutionary geneticist Asher Cutter proposes that we call this evolutionary meddling "genetic welding." In an opinion paper published March 28 in the journal Trends in Genetics, he argues that we must scientifically and ethically scrutinize the potential consequences of genetic welding before we put it into practice.

Researchers create new system for safer gene-drive testing and development.

#biotechnology #genedrives #CRISPR

https://phys.org/news/2023-01-safer-gene-drive.html

Researchers create new system for safer gene-drive testing and development

Scientists continue to expand the technological frontiers of CRISPR, along with its enormous potential, in areas ranging from human health to global food supplies. Such is the case with CRISPR-based gene drives, a genetic editing tool designed to influence how genetic elements are passed from one generation to the next.

Phys.org
Next was a fantastic group of talks by Jason Delborne, Omar Akbari, and Insoo Hyun on the #ethics and implications of #GeneDrives at the #HarvardMedicalSchool Center for #Bioethics. The rigor, process, and thought going into not just developing this technology but in engaging with a variety of stakeholders and inclusively advancing (or not) is very instructive, highly recommend https://www.youtube.com/watch?v=y_Erfg5_kFE (3/5)
A New Inheritance: Reshaping Our Environment with Gene Drives

YouTube

The promise (and worries) about gene drives. Article by Nature that gives a general overview on the following topics:

- Will gene drives even work?
- What else are gene drives good for?
- Can gene drives be controlled?
- How can gene drives be trialled?
- Who decides when to use a gene drive?

#Biology #Genetics #Evolution #Genes #GeneDrives

https://www.nature.com/articles/d41586-019-02087-5

The ethics of wiping out a mosquito species

The ethics of wiping out a mosquito species

Boing Boing
#Reading this NASEM committee report on #GeneDrives, interesting to see a) the extent to which e.g. mosquito species eradication by sexual reproduction appears doable today b) whether eradication or altering susceptibility/resistance, very genome and reproduction specific c) some impressive initial studies summarized on turning drives on and off.
wow, a WIRED article on #genedrives mentioning that US intelligence director James Clapper (yeah, *that* James Clapper) gave them a nod as a WMD/proliferation concern. Um, yeah... did anybody else see that breathless TED talk on eliminating malaria with gene drives and wonder what the presenter was smoking to have such rose-colored glasses? You can force a sterility mutation through a population in 3 generations. The described self-destructing a fruitfly population in the debut paper!