U3dnCH-47 Chinook Blank Livery Complex Animation #Blank #Helicopter #Chinook #Ch47 #Ch47f #Ch #47 #Ch47 #Boeing #Transport #Air #Force #Army #Military #War #AssetStore
https://u3dn.com/packages/ch-47-chinook-blank-livery-complex-animation-270137
Dahlia Moore (NSFW)Jeune femme au milieu d’un coup d’État...
https://litix.fr/seule-au-congo
#NSFW #bbc #doublepénétration #forcé #gangbang #groupe #interracial
Rxiv mechanobio📰 "How cargo driven by kinesin motors can pass efficiently through tau islands on microtubules"
https://doi.org/doi:10.1016/bs.apcsb.2025.10.027
https://pubmed.ncbi.nlm.nih.gov/41904015/
#Kinesin #Force
https://doi.org/doi:10.1016/bs.apcsb.2025.10.027
https://pubmed.ncbi.nlm.nih.gov/41904015/
#Kinesin #Force
Gopi Adusumilli 
Harshvardhan Rane studies for exams en route to the location of 'Force 3' #HarshvardhanRane #Force #socialnewsxyz
Harshvardhan Rane studies for exams en route to the location of 'Force 3' - Social News XYZ
Mumbai, March 29 (SocialNews.XYZ) Actor Harshvardhan Rane is presently occupied with the shoot of his action-packed drama "Force 3". However, the actor is also balancing studies with his work. In his latest story on... - Social News XYZ
📰 "The Degeneration Paradox: Severely Degenerated Cervical Nucleus Pulposus Cells Display Enhanced Mechanoplasticity Under Moderate Cyclic Tensile Strain"
https://doi.org/doi:10.3390/biom16030461
https://pubmed.ncbi.nlm.nih.gov/41897396/
#Force #Actin
https://doi.org/doi:10.3390/biom16030461
https://pubmed.ncbi.nlm.nih.gov/41897396/
#Force #Actin
CBC New BrunswickSaint John police officer faces charges related to use of force during an arrest
Both the Saint John Police Force and New Brunswick Public Prosecution Services independently asked the province's police oversight body to investigate the officer's use of force.
https://www.cbc.ca/news/canada/new-brunswick/charges-use-of-force-arrest-9.7145317?cmp=rss
Both the Saint John Police Force and New Brunswick Public Prosecution Services independently asked the province's police oversight body to investigate the officer's use of force.
https://www.cbc.ca/news/canada/new-brunswick/charges-use-of-force-arrest-9.7145317?cmp=rss
WIST QuotationsNow the bourgeois treasures nothing more highly than the self (rudimentary as his may be). And so at the cost of intensity, he achieves his own preservation and security. His harvest is a quiet mind which he prefers to being possessed by God, as he does comfort to pleasure, convenience to liberty, and a pleasant temperature to that deathly inner consuming fire. The bourgeois is consequently by nature a creature of weak impulses; anxious, fearful of giving himself away and easy to rule. Therefore, he has substituted majority for power, law for force, and the polling booth for responsibility.
[Der Bürger nun schätzt nichts höher als das Ich (ein nur rudimentär entwickeltes Ich allerdings). Auf Kosten der Intensität also erreicht er Erhaltung und Sicherheit, statt Gottbesessenheit erntet er Gewissensruhe, statt Lust Behagen, statt Freiheit Bequemlichkeit, statt tödlicher Glut eine angenehme Temperatur. Der Bürger ist deshalb seinem Wesen nach ein Geschöpf von schwachem Lebensantrieb, ängstlich, jede Preisgabe seiner selbst fürchtend, leicht zu regieren. Er hat darum an Stelle der Macht die Majorität gesetzt, an Stelle der Gewalt das Gesetz, an Stelle der Verantwortung das Abstimmungsverfahren.]
[Der Bürger nun schätzt nichts höher als das Ich (ein nur rudimentär entwickeltes Ich allerdings). Auf Kosten der Intensität also erreicht er Erhaltung und Sicherheit, statt Gottbesessenheit erntet er Gewissensruhe, statt Lust Behagen, statt Freiheit Bequemlichkeit, statt tödlicher Glut eine angenehme Temperatur. Der Bürger ist deshalb seinem Wesen nach ein Geschöpf von schwachem Lebensantrieb, ängstlich, jede Preisgabe seiner selbst fürchtend, leicht zu regieren. Er hat darum an Stelle der Macht die Majorität gesetzt, an Stelle der Gewalt das Gesetz, an Stelle der Verantwortung das Abstimmungsverfahren.]
Herman Hesse (1877-1962) German-born Swiss poet, novelist, painter
Steppenwolf, “Treatise of the Steppenwolf,” ch. 2 (1927) [tr Breighton (1929)]
More about (and translations of) this quote: wist.info/hesse-herman/82858/
#quote #quotes #quotation #qotd #hermanhesse #steppenwolf #bourgeois #calm #comfort #convenience #democracy #force #law #liberty #majorityrule #peaceandquiet #power #responsibility #security #selfpreservation #tyrannyofthemajority
Hesse, Herman - Steppenwolf, "Treatise of the Steppenwolf," ch. 2 (1927) [tr Breighton (1929)] | WIST Quotations
Now the bourgeois treasures nothing more highly than the self (rudimentary as his may be). And so at the cost of intensity, he achieves his own preservation and security. His harvest is a quiet mind which he prefers to being possessed by God, as he does comfort to pleasure, convenience…
📰 "Neck-region-microtubule interactions direct counterclockwise stepping of kinesin-1"
https://doi.org/doi:10.1016/j.bpj.2026.03.043
https://pubmed.ncbi.nlm.nih.gov/41889176/
#Microtubule #Kinesin #Force
https://doi.org/doi:10.1016/j.bpj.2026.03.043
https://pubmed.ncbi.nlm.nih.gov/41889176/
#Microtubule #Kinesin #Force
Kyiv Independent Daily HeadlinesThursday, March 26, 2026
Worst oil supply disruption in modern Russian history halts about 40% of export capacity, Reuters reports -- 'Land for security' in Ukraine negotiations must be rejected -- Ukrainian drones attack major oil and gas facilities in Russia's Leningrad Oblast for second night in row ... and morehttps://activitypub.writeworks.uk/2026/03/thursday-march-26-2026/
📰 "Molecular mechanics of smooth muscle contraction and relaxation modulated by caldesmon"
https://www.biorxiv.org/content/10.64898/2026.03.23.713758v1?rss=1 #Mechanics #Myosin #Force
https://www.biorxiv.org/content/10.64898/2026.03.23.713758v1?rss=1 #Mechanics #Myosin #Force
Molecular mechanics of smooth muscle contraction and relaxation modulated by caldesmon
Smooth muscle (SM) contraction is well known to be regulated by the reversible phosphorylation of the myosin regulatory light chain. However, SM force generation and relaxation are often uncoupled from myosin phosphorylation levels (e.g. the latch-state), indicating that additional regulatory mechanisms must be at play. The precise effects of the actin binding protein caldesmon (CaD) on SM force production and relaxation remain ambiguous, largely due to contradictory findings in experiments performed at the tissue level. To date, there are no studies that have measured the effects of CaD on force and relaxation at the molecular level. Here, we use a laser-trap assay to measure the force produced by SM myosin molecules in the presence and absence of CaD. Measurements were performed before and during myosin dephosphorylation, thus simulating SM contraction and relaxation in-vitro. We demonstrate that CaD inhibits force generation, most likely through competitive inhibition of actomyosin binding while simultaneously introducing a resistive load via tethering of actin and myosin. We also establish CaD as a potentiator of relaxation, increasing force decay rate during myosin dephosphorylation. Finally, we show that CaD directly modulates the dependence of myosin-actin mechanics on myosin phosphorylation levels. These findings refine our understanding of SM regulation, highlighting CaD not merely as a passive structural stabilizer, but as a critical regulatory component of force development and relaxation. Ultimately, understanding these mechanical functions offers new perspectives on pathophysiologies involving SM, such as asthma, hypertension, and gastrointestinal disorders, potentially guiding targeted therapeutic strategies. ### Competing Interest Statement The authors have declared no competing interest. Natural Sciences and Engineering Research Council, https://ror.org/01h531d29, RGPIN-2024-06906, PGSD-5898942024