Ferroportin is the only human iron exporter, suppressed by the peptide hormone
#hepcidin. The structure of
#ferroportin bound to hepcidin mimetic peptide PR73 reveals novel interactions and explains the enhanced affinity of PR73 @bcmhouston
#PLOSBiology https://plos.io/3ZKnwnJ
Structural basis of ferroportin inhibition by minihepcidin PR73
Ferroportin is the only known iron exporter in humans, and its suppressed by hepcidin, an endogenous peptide hormone. The structure of human ferroportin bound to the hepcidin mimetic peptide PR73 reveals interactions not seen in the hepcidin-ferroportin complex and provides a rationale for the enhanced affinity of PR73.
Ferroportin is the only human iron exporter, suppressed by the peptide hormone
#hepcidin. The structure of
#ferroportin bound to hepcidin mimetic peptide PR73 reveals novel interactions and explains the enhanced affinity of PR73 @bcmhouston
#PLOSBiology https://plos.io/3ZKnwnJStructural basis of ferroportin inhibition by minihepcidin PR73
Ferroportin is the only known iron exporter in humans, and its suppressed by hepcidin, an endogenous peptide hormone. The structure of human ferroportin bound to the hepcidin mimetic peptide PR73 reveals interactions not seen in the hepcidin-ferroportin complex and provides a rationale for the enhanced affinity of PR73.
Ferroportin is the only human iron exporter, suppressed by the peptide hormone
#hepcidin. The structure of
#ferroportin bound to hepcidin mimetic peptide PR73 reveals novel interactions and explains the enhanced affinity of PR73 @bcmhouston
#PLOSBiology https://plos.io/3ZKnwnJStructural basis of ferroportin inhibition by minihepcidin PR73
Ferroportin is the only known iron exporter in humans, and its suppressed by hepcidin, an endogenous peptide hormone. The structure of human ferroportin bound to the hepcidin mimetic peptide PR73 reveals interactions not seen in the hepcidin-ferroportin complex and provides a rationale for the enhanced affinity of PR73.
“Molecular prosthetic” when the iron-transporting protein
#ferroportin is missing or defective, offering a potential treatment path for
#ferroportin disease and certain kinds of
#anemia.
#Chemistry #Biology #sflorghttps://www.sflorg.com/2022/06/ch06242201.html
Small molecules transport iron in mice, and human cells to treat some forms of anemia
This is a really striking demonstration in a whole animal model that an imperfect mimic of a missing protein can reestablish physiology
PLOS Biology
Scientific Frontline