Well, crap.
P-CABs and #PPIs associated with higher risk of #stroke in patients taking #clopidogrel.
Info: patients taking a blood thinner to prevent recurrent stroke are at higher risk of #bleeding, including gastric bleeding. PPIs are frequently co-prescribed to reduce the risk of GI bleeding. (There is nuance, please consult your doctor. I am not a doctor.)
https://www.ahajournals.org/doi/suppl/10.1161/STROKEAHA.125.053616
Clopidogrel Found to Be More Effective than Aspirin in Preventing Heart Attacks and Strokes
A groundbreaking study has revealed that clopidogrel, a commonly prescribed blood thinner, is more effective than aspirin in preventing heart attacks and strokes, without increasing the risk of major bleeding. The discovery was made by an international team of researchers who analyzed data from near... [More info]
https://www.nejm.org/doi/full/10.1056/NEJMoa2309137
Antiplaquetario doble (con todo y dosis de carga) disminuye el riesgo de reincidencia en pacientes con #Stroke cuando se inicia de manera temprana, aunque aumenta el riesgo de #sangrado.
#EVC #Aspirina #Clopidogrel #Neurología #AIT #TIA #Neurology #Aspirin
Evidencia de que el tratamiento antiplaquetario doble #aspirina + #clopidogrel iniciado rápidamente después de un #EVC isquémico leve o de un #AIT de alto riesgo disminuye más el riesgo de recurrencia que sólo aspirina, elevando el riesgo de #sangrado.
Dual anti platelet therapy (aspirine+clopidogrel) after mild ischemic #stroke or high risk #TIA shows greater risk reduction for new stroke than #aspirin alone, with > #bleeding risk
#Neurology #Neurología
https://www.nejm.org/doi/full/10.1056/NEJMoa2309137
#Clopidogrel, #Prasugrel und #Ticagrelor: Für Netzwerk-Metaanalyse fehlen Daten
Ein Hersteller übermittelte angeforderte zusätzliche Daten nicht. Explorative Analysen zeigen aber, dass diese wichtig gewesen wären.
Linda
David McFarlane
grimer0203 at KillBait
Chuck Darwin
René
IQWiG