I just moved @gregory_ms from Med-Mastodon to the main Mastodon.social. Expect some glitches, again. 😬

#MSchat #BotsFightMS #multipleSclerosis #Neurology

Novel cerebrospinal fluid anti-central nervous system IgG antibodies can identify immunotherapy-responsive neuropsychiatric disorders

Autoantibodies targeting the central nervous system (CNS) can cause various neuropsychiatric autoimmune diseases. The potential response to immunotherapy necessitates the continuous expansion of Ab testing strategies. This study screened cerebrospinal flu ...

https://gregory-ms.com/articles/298928/

#MSchat #MS #Neurology #MultipleSclerosis #botsFightMS

Overexpression of endothelial β4integrin has no impact on blood-brain barrier integrity or the pathogenesis of experimental autoimmune encephalomyelitis

Laminin is. major component of the vascular basement membrane. Transgenic mice deficient in laminin manifest blood-brain barrier (BBB) disruption. Laminin receptor α6β4 integrin is strongly induced on CNS blood vessels in the neuroinflam ...

https://gregory-ms.com/articles/298932/

#MSchat #MS #Neurology #MultipleSclerosis #botsFightMS

Decoding the molecular and cellular aspects of multiple sclerosis: From diagnosis to therapeutic strategies

Multiple sclerosis (MS) is. chronic neuroinflammatory condition of the central nervous system marked by demyelination, gliosis, and axonal degradation. The exact etiology of MS remains unclear. The article methodologically synthesizes data from genome-wide associati ...

https://gregory-ms.com/articles/298933/

#MSchat #MS #Neurology #MultipleSclerosis #botsFightMS

Activation of the Immunoregulatory Cation Channel TMEM176B by a Nitroalkene Derivative of Salicylate Prolongs Graft Survival

Transmembrane protein 176B (TMEM176B) is an intracellular cation channel highly expressed by myeloid cells. It controls the tolerogenic function of dendritic cells and inhibits NOD, LRR, and pyrin domain-containing protein. inflammasome. SANA is an activator of TMEM176b-de ...

https://gregory-ms.com/articles/298935/

#MSchat #MS #Neurology #MultipleSclerosis #botsFightMS

Regulation of dendritic cell biology by amino acids and their transporters

Dendritic cells (DCs) play. central role in inducing immunity and tolerance as specialized antigen-presenting cells (APCs). The immunometabolic firestorm in recent years has focused attention on how DCs use energy and respond to nutritional changes that affect immune functions. Dysregulation of amino acid metabolism ...

https://gregory-ms.com/articles/298867/

#MSchat #MS #Neurology #MultipleSclerosis #botsFightMS

A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS)

https://clinicaltrials.gov/study/NCT07074886?term=ocrelizumab

#MSchat #Neurology #MultipleSclerosis #ClinicalTrial #botsFightMS