https://gregory-ms.com/articles/316414/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_316414

Natural compound anacardic acid has been shown to bind and inhibit the first enzyme in the SUMOylation pathway. Stimulation of splenocytes with LPS resulted in reduced production of inflammatory mediators. AA treatment significantly reduced clinical paralysis and pathological CNS inflammation in experimental allergic encephalomyelitis (EAE), an animal model of multiple sclerosis.

#MultipleSclerosis #MSchat #MS #Neurology

https://gregory-ms.com/articles/316428/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_316428

#MultipleSclerosis #MSchat #MS #Neurology

Clinical trial: TSC Alliance Tuberous Sclerosis Complex (TSC) Biosample Repository and Natural History Database

https://clinicaltrials.gov/study/NCT05676099?utm_source=fediverse&utm_medium=mastodon&utm_content=trial_10845

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

Clinical trial: A Pilot Study to Investigate Glymphatic System Alterations in Vivo in Patients With Clinically Isolated Syndrome, Using Magnetic Resonance Imaging

https://clinicaltrials.gov/study/NCT06274671?utm_source=fediverse&utm_medium=mastodon&utm_content=trial_20576

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

Clinical trial: Periodontal Inflammation in Rare Renal Disorders - A Cross-Sectional Controlled Observational Study Assessing the Burden and Phenotypes of Periodontal Disease

https://clinicaltrials.gov/study/NCT07575347?utm_source=fediverse&utm_medium=mastodon&utm_content=trial_20577

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

Clinical trial: Single Arm Trial Identifying Barriers and Facilitators to Mindfulness Practice

https://clinicaltrials.gov/study/NCT07573241?utm_source=fediverse&utm_medium=mastodon&utm_content=trial_20565

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

Clinical trial: Identification of Gait Disorders in Children, Adolescents and Young Adults With Rare Genetic Diseases

https://clinicaltrials.gov/study/NCT05161494?utm_source=fediverse&utm_medium=mastodon&utm_content=trial_20566

#ClinicalTrials #MultipleSclerosis #MSchat #Neurology

https://gregory-ms.com/articles/316204/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_316204

#MultipleSclerosis #MSchat #MS #Neurology

https://gregory-ms.com/articles/316276/?utm_source=fediverse&utm_medium=mastodon&utm_content=article_316276

Irisin, an exercise-induced myokine, has been reported to exhibit neuroprotective effects, including anti-inflammatory activity and cognitive improvement. In the experimental autoimmune encephalomyelitis (EAE) mouse model, irisin treatment significantly alleviated EAE severity, reduced disease incidence, attenuated weight loss and improved neurological scores.

#MultipleSclerosis #MSchat #MS #Neurology