A few years ago, I tried setting up Guix System on WSL2. I succeeded after going through obscure GitHub issues and gists. Eventually, I stopped tinkering with it due to lack of time, but I'm happy to say that if I wanted to try again it's relatively easy to get a working Guix System on WSL2 with or without a working guix!
Arian Dehghani explains in his blog [2] that Guix provides an image builder for WSL2 such that you can install Guix on WSL2 simply by importing a (suspicious) pre-built tarball [1]!
[1] https://github.com/Arian-D/guix-wsl/
[2] https://arian-d.github.io/blog/posts/guix-on-wsl/
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