Mastodawn

First paper of 2026 out of the door

Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells | Nature Chemical Biology

#Science #Research #SeeMyScience #Glycobiology

https://www.nature.com/articles/s41589-025-02113-w

Xylosyltransferase engineering to manipulate proteoglycans in mammalian cells - Nature Chemical Biology

The xylosyltransferase isoenzymes XT1 and XT2 catalyze the first glycosylation step in the biosynthesis of proteoglycans. Now, bump-and-hole engineering of XT1 and XT2 enables substrate profiling and modification of proteins as designer proteoglycans to modulate cellular behavior.

Nature

Stephen Royle Dec 13, 2023

The training looks like it is starting to converge and should be near to completion.

Each epoch is about 100 minutes. I couldn't get nnU-net to use metal with pytorch on my mac so it's going really slow. Plus, the data I am using for training is big.

#LearningMachineLearning #LifeOfPI #SeeMyScience