xtaldaveDec 21

Chemoenzymatic Synthesis and Purification of Bioorthogonally Tagged UDP-GlcNAc and UDP-GalNAc Analogues - PubMed

Useful for the glycobiologist in your life
#Glycobiology #Chemistry

https://pubmed.ncbi.nlm.nih.gov/41405877/

Chemoenzymatic Synthesis and Purification of Bioorthogonally Tagged UDP-GlcNAc and UDP-GalNAc Analogues - PubMed

Nucleotide-sugar donors containing bioorthogonal moieties are important tools to study cellular glycosylation. Typically, the acetamide moiety in N-acetylhexosamines such as GlcNAc and GalNAc is replaced by an acylamide with a clickable tag and converted to the corresponding uridine diphosphate anal …

PubMed
xtaldaveDec 17

New server, new #introduction

Hi, I'm Dave. I'm a Research #Scientist at a Research Institute in #London, #UK

I'm a #StructuralBiologist by training. I help run a group that studies #Kinase #signalling in human #health and #disease.

In my spare time I swear a lot, play #bass and walk #dogs.

I do #Crystallography #CryoEM #Biophysics #DrugDesign and #Glycobiology. #Science #Research

Sweet Paper BotNov 21
Meeting Report on the 1st GlyCosmos Symposium & Jamboree —Community-Driven Expansion of Glycan-Binding Molecules Resources
https://academic.oup.com/glycob/advance-article/doi/10.1093/glycob/cwaf079/8339877?rss=1
#Glycotime #Glycobiology
Stephan HackerNov 7
Insightful talk by Jeroen Codee at the #Reedijk Symposium. He talked about the importance of synthetic organic chemistry to make complex glycans to better understand #glycobiology. Very impressive, systematic work on glycosylation reactions. pubs.rsc.org/en/content/a... #ChemSky #ChemBio #Glycotime
Stephan HackerNov 7
Insightful talk by Jeroen Codee at the #Reedijk Symposium. He talked about the importance of synthetic organic chemistry to make complex glycans to better understand #glycobiology. Very impressive, systematic work on glycosylation reactions. https://pubs.rsc.org/en/content/articlelanding/2023/sc/d2sc06139b
#ChemSky #ChemBio #Glycotime
CC: @LED3hub
GlyGenMay 23, 2025

📝 New paper from the GlyGen Consortium authored by Dr. Robel Kahsay: GlycoSiteMiner—an ML/AI-assisted pipeline for mining glycosylation sites from PubMed abstracts. Published in Glycobiology.

#glycotime #bioinformatics #glycobiology

Show threadRhyothemisDec 10, 2024

@Nonya_Bidniss

"Brevican (BCAN) ... and growth differentiation factor 15 ... showed the most significant, and multiple, associations with dementia, stroke and movement functions."
https://www.nature.com/articles/s43587-024-00753-6

"Brevican is a secreted member of the lectican/hyalectan family of hyaluronan-binding chondroitin sulfate proteoglycans (CSPGs; (Faissner et al., 2010)). Mediated by binding of homologous C-type lectin motifs in the C-terminal domain, brevican comprises a structural factor of the ECM together with tenascins and hyalurolan (Bekku et al., 2009). It is predominantly present in perineuronal nets (PNNs) of the adult CNS and is transiently expressed by neurons during development."
https://www.sciencedirect.com/science/article/pii/S0301008216300478

#glycobiology #perineuronalnets #neuroscience #aging #ExtracellularMatrix

Plasma proteomics identify biomarkers and undulating changes of brain aging - Nature Aging

Using proteomics and imaging data from UK Biobank, the authors identified multiple circulating proteins associated with brain aging and discovered undulating age-related changes in the plasma proteome, with peaks occurring at 57, 70 and 78 years of age.

Nature
RhyothemisNov 29, 2024

How our Gut Bacteria Can Fight Tumor Growth
https://www.mygenefood.com/blog/gut-bacteria-can-fight-tumor-growth/

comment: fucoidan, found in seaweeds such as wakame, is a source of fucose for fucosylation

#GutMicrobiome #probiotics #glycobiology #tumorigenesis

How our Gut Bacteria Can Fight Tumor Growth - Gene Food

The average adult gut extends over 20 feet and is the home of over a thousand different bacteria species, all with specific roles to play in digestion. In fact, science... Read More

Gene Food
GlycoShapeOct 14, 2024

Some exciting #glycotime to start the week!

GlycoShape is fresh off the press today on Nature Methods https://www.nature.com/articles/s41592-024-02464-7  

Check out the short thread below 1/6

#Science #ProteinStructure #glycobiology

Restoring protein glycosylation with GlycoShape - Nature Methods

GlycoShape is an open-access web-based platform designed to supplement three-dimensional glycoprotein structures with missing structural information on glycans. To link them, the Re-Glyco algorithm evaluates the steric complementarity of glycans using their conformational ensemble with the protein surface.

Nature
RhyothemisSep 9, 2024

Glycosylation Modulates the Structure and Functions of Collagen: A Review (2024)

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11012932/

#collagen #ConnectiveTissue #ExtracellularMatrix #glycosylation #glycobiology

Glycosylation Modulates the Structure and Functions of Collagen: A Review

Collagens are fundamental constituents of the extracellular matrix and are the most abundant proteins in mammals. Collagens belong to the family of fibrous or fiber-forming proteins that self-assemble into fibrils that define their mechanical properties ...

PubMed Central (PMC)