Surprise 4th category pulling out the "unseen" lobular #bcsm due to distinct biology

📣 Call to action to have more discussion about it as a distinct subtype

@[email protected] #SABCS22 @[email protected]

Real ❓s being raised about whether proton XRT ☢️ should be used in #bcsm. It's already available out in the real world 🗺.

In my practice, I have seen MUCH worse skin toxicity w/ protons compared to photons. 😬 Lucile uptake has not been brisk, but it's worrisome.

#SABCS22

#GeparOLA compares pac/carbo vs. pac/Olaparib in OFS with HER-2 beg and HRD def #bcsm

🔹Carbo combo results in numerically higher iDFS, DDFS? And OS compared to olaparib combo.

🔹Particularly prominent improvement in BRCAwt

#SABCS22 @[email protected]

So....who knows how I can get a dinner invite with Norman Wolmark?

Brilliant, hilarious, and a fabulous story teller!

"are they going to pull me off the stage?"

"so they wanted the results BEFORE they would fund the trial?"

"As I approach my use by date..."

#SABCS22

POSITIVE trial looked at stopping ET to attempt 🤰 among women <42 yrs old that had received 18-30 months of ET

No increase in recurrence risk with cessation of ET for pregnancy compared to historical controls

74% of women had at least 1 pregnancy

#SABCS22 @[email protected]