#ProteinQC pathways play key roles in resistance to
#pathogens. @manishgrover_4 @barkoulab &co show that
#proteasome regulation keeps
#InnateImmune responses against natural pathogens of
#Celegans in check in a tissue-specific manner
#PLOSBiology https://plos.io/3PhIjLW 
Proteasome inhibition triggers tissue-specific immune responses against different pathogens in C. elegans
Protein quality control pathways play important roles in resistance against pathogen infection. This study shows that proteasome regulation keeps innate immune responses in check in a tissue-specific manner, against natural eukaryotic pathogens of the C. elegans epidermis and intestine.
Failure of
#ProteinQC in
#Celegans triggers a mechanism involving pathogen response factors &
#lysosome-mediated degradation, promoting tissue-specific resilience to age-dependent
#ProteinAggregation &
#proteotoxicity @DellaDavid_Lab &co
#PLOSBiology https://plos.io/44QeDdD
A safety mechanism enables tissue-specific resistance to protein aggregation during aging in C. elegans
This study shows that during failure of core protein quality control in C. elegans, a specialized anti-aggregation mechanism relying on intracellular pathogen response factors and lysosomal mediated degradation is triggered, promoting tissue-specific resilience to age-dependent protein aggregation and its proteotoxicity.
PLOS Biology
