🌟 Decoding Dinner: Precision Nutrition, DNA, and the Future of Your Fork 🌟
Imagine a world where your meals are as unique as your DNA! Precision nutrition is transforming our plates into personalized health powerhouses. Say goodbye to one-size-fits-all diets and hello to a future of bespoke nutrition.
Read more: https://solar-kitties.beehiiv.com/p/decoding-dinner-precision-nutrition-dna-and-the-future-of-your-fork
#PrecisionNutrition #FutureOfFood #SolarKitties
Decoding Dinner: Precision Nutrition, DNA, and the Future of Your Fork...
We are standing at the precipice of an era where your plate will be as unique as your fingerprint, guided by the intricate symphony of your genes. The question isn't if this will happen, but how quickly it will reshape our markets, our medicine, and our very understanding of what it means to be well.
'Effect of the Variant rs7903146 of Transcription Factor 7-Like 2 Gene on Anthropometric and Metabolic Responses to a 24 Weeks Meal Replacement Hypocaloric Diet' - an article in Karger: Nutrition and Dietetics on #ScienceOpen:
🔗 https://www.scienceopen.com/document?vid=ad3f252c-ae55-4e25-ad28-ee54c83e0b0e
#NutritionResearch #MetabolicHealth #Genomics #MetabolicSyndrome #PrecisionNutrition
Effect of the Variant rs7903146 of Transcription Factor 7-Like 2 Gene on Anthropometric and Metabolic Responses to a 24 Weeks Meal Replacement Hypocaloric Diet
<p xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" dir="auto" id="d6618e132">
<b>
<i>Introduction:</i>
</b> Some studies have demonstrated the effect of the rs7903146 genetic variant on weight
response after different dietary strategies. The objective of our study was to evaluate
the role of this genetic variant of the
<i>TCF7L2</i> gene on weight loss and diabetes mellitus progression following a partial meal replacement
(pMR) hypocaloric diet.
<b>
<i>Methods:</i>
</b> We conducted an interventional study in 214 subjects with obesity and a body mass
index (BMI) >35 kg/m
<sup>2</sup>. The subjects received two servings per day of a normocaloric hyperproteic formula
for 24 weeks as part of a pMR diet. Body weight, BMI, fat mass, waist circumference,
lipid profile, fasting insulin levels, and HOMA-IR were determined. All patients were
genotyped for rs7903146 and evaluated under a dominant model (CC vs. CT + TT).
<b>
<i>Results:</i>
</b> The decrease at 24 weeks was higher in non-T-allele carriers compared to T-allele
carriers (BMI: −3.3 ± 0.3 kg/m
<sup>2</sup> vs. −2.2 ± 0.2 kg/m
<sup>2</sup>;
<i>p</i> = 0.02; weight: −9.5 ± 1.1 kg vs. −5.0 ± 1.0 kg;
<i>p</i> = 0.01; fat mass: −8.7 ± 0.2 kg vs. −4.0 ± 0.2 kg;
<i>p</i> = 0.04; waist circumference: −8.0 ± 0.2 cm vs. −3.0 ± 0.4 cm;
<i>p</i> = 0.04; glucose levels: −7.1 ± 1.2 mg/dL vs. −1.2 ± 1.1 mg/dL;
<i>p</i> = 0.01; insulin: −10.1 ± 1.1 µIU/L vs. −4.0 ± 1.0 µIU/L;
<i>p</i> = 0.01; HOMA-IR: −2.1 ± 1.1 units vs. −0.5 ± 0.1 units;
<i>p</i> = 0.01; C-reactive protein: −0.9 ± 0.1 mg/dL vs. −0.4 ± 0.2 mg/dL;
<i>p</i> = 0.01; triglycerides: −17.1 ± 0.1 mg/dL vs. −9.1 ± 0.2 mg/dL;
<i>p</i> = 0.01; and HbA1c: −1 ± 0.1% vs. −0.3 ± 0.2%;
<i>p</i> = 0.01). Following the dietary intervention, only non-T-allele carriers showed a
significant decrease in the frequency of hypertriglyceridemia, abdominal waist, hyperglycemia,
and DM2.
<b>
<i>Conclusions:</i>
</b> The
<i>TCF7L2</i> (rs7903146) polymorphism modulates pMR diet-induced changes in body weight, lipid
metabolism, and insulin resistance. These changes lead to a significant decrease in
the prevalence of hyperglycemia and other components of metabolic syndrome.
</p>
Nutrition scientists are excited about the possibilities for a
#MixedMealToleranceTest. New research in Nutrition & Diabetes suggests that such a test might be a marker of dietary disease risk and tool for
#PrecisionNutrition.
https://conscienhealth.org/2024/08/the-possibility-of-a-better-measure-for-dietary-disease-risk/
The Possibility of a Better Measure for Dietary Disease Risk - ConscienHealth
New research points to the potential for better measures of dietary disease risk that could open the way to advances in precision nutrition.
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