mechanochemistry🚨NEW PREPRINT🚨
Michael Smutny's lab have a new paper on bioRxiv on the mechanics of the early neural plate. Check it out!
Inman et al.
A multi-tiered mechanical mechanism shapes the early neural plate
New paper from Saunders lab:
Curvature-Induced Cell Rearrangements in Biological Tissues
https://journals.aps.org/prl/abstract/10.1103/PhysRevLett.130.108401
Curvature-Induced Cell Rearrangements in Biological Tissues
On a curved surface, epithelial cells can adapt to geometric constraints by tilting and by exchanging their neighbors from apical to basal sides, known as an apico-basal topological transition 1 (AB-T1). The relationship between cell tilt, AB-T1s, and tissue curvature still lacks a unified understanding. Here, we propose a general framework for cell packing in curved environments and explain the formation of AB-T1s from the perspective of strain anisotropy. We find that steep curvature gradients can lead to cell tilting and induce AB-T1s. Alternatively, pressure differences across the epithelial tissue can drive AB-T1s in regions of large curvature anisotropy. The two mechanisms compete to determine the impact of tissue geometry and mechanics on optimized cell rearrangements in three dimensions.
New preprint from Yean Ming in the Cross lab showing how microtubules composed of specified tubulin isotypes respond differently to taxol
https://www.biorxiv.org/content/10.1101/2023.02.07.527540v1
#CellBiology #Microtubules #Cytoskeleton #Motors #Preprint #PaperToot
Age-dependent loss of cohesion protection in human oocytes
Royle Lab NewsA few months earlier, @NFerrandiz with help from Laura and George reported chromosome ensheathing during mitosis. #CellBiology #PaperToot
https://doi.org/10.1083/jcb.202203021
This paper had a wonderful spotlight article by Donker & Godinho. https://doi.org/10.1083/jcb.202204114 and was picked as one of @JCellBiol 's papers of 2022 https://rupress.org/jcb/collection/21549/The-Year-in-Cell-Biology-2022
We have several new papers brewing for 2023 - stay tuned. Happy holidays.
Endomembranes promote chromosome missegregation by ensheathing misaligned chromosomes | Journal of Cell Biology | Rockefeller University Press
Ferrandiz et al. found that misaligned chromosomes, arising from errors in mitosis, can become “ensheathed” in endomembranes. Ensheathing biases chromosomes tow
In 2022, our lab published two papers that we'd like to highlight. First, in July Cansu, with some help from Méghane, Gabrielle and Miguel described "MitoPits". These are clathrin-coated pits that are induced to form on mitochondria! Weirder than that, they can bud to form vesicles...
