PLOS BiologyFeb 4, 2025
How is transport directionality achieved through the #trypanosome nuclear pore complex? The current model is symmetrical, but this study reveals that the trypanosome #NuclearPore has an asymmetrical architecture, with conserved hubs that direct mRNA transport #plosbiology https://plos.io/3Q36QV2
Detailed characterisation of the trypanosome nuclear pore architecture reveals conserved asymmetrical functional hubs that drive mRNA export

How transport directionality is achieved through the trypanosome nuclear pore complex is unclear, as the current structural model is mostly symmetrical. Using a combination of expansion microscopy and proximity labeling, this study reveals that the trypanosome nuclear pore has an asymmetrical architecture, with conserved hubs that direct mRNA transport.

CRAIG M CREWSNov 9, 2022

My #Yale colleague Christian Schlieker has a nice story showing that FG-nucleoporins form aberrant condensates and contribute to DYT1 dystonia. Torsin. #nuclearpore #cellbiology

https://www.nature.com/articles/s41556-022-01001-y

Atypical nuclear envelope condensates linked to neurological disorders reveal nucleoporin-directed chaperone activities - Nature Cell Biology

Kuiper et al. and Prophet et al. implicate DNAJB6/HSP70 chaperone activities in the biogenesis of the nuclear pore complex permeability barrier and find that disease-linked nuclear envelope blebs are enriched in nucleoporin and chaperone condensates.

Nature