Gal Haimovich 😷🔬☣🏳️🌈🏳️⚧New pre-print from Voula Mili lab.
she suggests that mRNA localization and translation rate determine the localization of a protein which is found both in nucleus and cytoplasm.
I'll need to find time to dive it and read in detail.
📣 💥 It took almost 12 years, but the final paper from my PhD is finally published @naturecomms
It is titled “RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway” but the somewhat dry title hides a novel nuclear import mechanism that we discovered.
https://www.nature.com/articles/s41467-022-34417-z
A 🧵:
#mRNA #mRNADegradation #GeneExpression #yeast #nucleus #NuclearImport #RiboRegulation
RNA-controlled nucleocytoplasmic shuttling of mRNA decay factors regulates mRNA synthesis and a novel mRNA decay pathway - Nature Communications
Nucleocytoplasmic shuttling of several yeast mRNA decay factors regulates transcription and initiates a novel mRNA decay pathway; shuttling is controlled by the decaying RNA and is critical for coping with environmental changes.