Mastodawn

Yet another ddAVP trial for kidney biopsies with neutral results academic.oup.com/ckj/advance-... In Clinical Kidney Journal Previous #NephJC discussion: www.nephjc.com/news/ddavp

Bleeding prevention with desmo...

hswapnil 2d ago

Yet another ddAVP trial for kidney biopsies with neutral results

https://academic.oup.com/ckj/advance-article/doi/10.1093/ckj/sfag083/8516492

In Clinical Kidney Journal

Previous #NephJC discussion: https://www.nephjc.com/news/ddavp

Swapnil Hiremath 🍁🇨🇦6d ago

Swapnil Hiremath #NephJC Sorry just returning from our #NephMadness party - joining in late

Swapnil Hiremath 🍁🇨🇦Mar 5

Can an ineffective intervention be cost-effective? Cristina Popa breaks down the latest low protein diet proponents insipid attempt for a #NephJC Shorts www.nephjc.com/news/2026/2/...

Dialysis delay at what cost? P...

Dialysis delay at what cost? Protein restriction as a distraction in the age of GDMT — NephJC

The NephJC shorts on cost-efficiency of low-protein diets and ketoanalogues as a distraction from CKD-relevant therapies in the 21st century… wait, only if the comparator wouldn’t be dialysis.

NephJC

Swapnil Hiremath

MD Mar 5

Can an ineffective intervention be cost-effective?

Cristina Popa breaks down the latest low protein diet proponents insipid attempt for a #NephJC Shorts

https://www.nephjc.com/news/2026/2/27low-protein-diet-costs

Dialysis delay at what cost? Protein restriction as a distraction in the age of GDMT — NephJC

The NephJC shorts on cost-efficiency of low-protein diets and ketoanalogues as a distraction from CKD-relevant therapies in the 21st century… wait, only if the comparator wouldn’t be dialysis.

NephJC

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Swapnil Hiremath 🍁🇨🇦Feb 25

To me, it is difficult to justify a placebo controlled trial without proper guardrails (not transfusion - rescue ESA maybe) which was done in the non-dialysis trials In dialysis patients with anemia, how do you justify withholding ESA (which is standard of care)? #NephJC

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Swapnil Hiremath 🍁🇨🇦Feb 25

There was some intriguing data for HIF in inflammation or high hepcidin states - but I haven’t seen good data - I guess the field has moved to trying Ziktekevimab etc instead? #NephJC

Swapnil Hiremath 🍁🇨🇦Feb 25

Yeah: cost & convenience As @[email protected] said last night in India the HIF is 60% of the ESA The original HIF:ESA trials were designed as non-inferiority for this reason, since the lower cost and pills versus injections would justify an NI design #NephJC

Swapnil Hiremath 🍁🇨🇦Feb 25

#NephJC What do you think of @[email protected] Q here?

RE: https://bsky.app/profile/did:plc:7upc425urivkcj2z6tvhzxlq/post/3mfnndzb6222d

Swapnil Hiremath 🍁🇨🇦Feb 25

I go up to 1200 based on DRIVE pubmed.ncbi.nlm.nih.gov/17267740/ in @[email protected] #JASN What’s your upper limit of tolerance for ferritin? #NephJC

Ferric gluconate is highly eff...

Ferric gluconate is highly efficacious in anemic hemodialysis patients with high serum ferritin and low transferrin saturation: results of the Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) Study - PubMed

Few data exist to guide treatment of anemic hemodialysis patients with high ferritin and low transferrin saturation (TSAT). The Dialysis Patients' Response to IV Iron with Elevated Ferritin (DRIVE) trial was designed to evaluate the efficacy of intravenous ferric gluconate in such patients. Inclusio …

PubMed