GreenSupplyChain DIHJan 13, 2025
🗣️ Have your say by filling in the Horizon #TRIBIOME project survey, aiming to collect data useful for building a decision support network for experimenters in the field of #biostimulants and #modulators, with a focus on #organic #crops💡
https://www.linkedin.com/posts/eu-cap-network_agriculture-horizoneurope-organicfarming-activity-7282686152849932288-SUUF?utm_source=share&utm_medium=member_ios
SubtleBlade ⚔️Aug 25, 2024

‘Real hope’ for #CysticFibrosis patients as #NHS rolls out life-changing drug

Campaigners hail decision to give thousands of sufferers access to new set of drugs known as ‘#modulators’
https://www.theguardian.com/society/article/2024/aug/25/real-hope-for-cystic-fibrosis-patients-as-nhs-rolls-out-life-changing-drug
#Health

‘Real hope’ for cystic fibrosis patients as NHS rolls out life-changing drug

Campaigners hail decision to give thousands of sufferers access to new set of drugs known as ‘modulators’

The Guardian
ℵ₀ 🏳️‍⚧️🏴‍☠️Jul 19, 2023

Structure–Activity Relationship #Study of #Cannabidiol-Based #Analogs as Negative #Allosteric #Modulators of the μ-#Opioid #Receptor

https://pubs.acs.org/doi/epdf/10.1021/acs.jmedchem.3c00061

“The US faces an unprecedented surge in fatal drug overdoses. Naloxone, the only antidote for opiate overdose, competes at the mu opioid receptor (μOR) orthosteric site. Naloxone struggles against fentanyl-class synthetic opioids that now cause ∼80% of deaths.”

Show threadTRMCRCLRM | TWRNSLKTHJun 2, 2023
Risking to get on your nerves with my toots about "Boodo Khan" there's still one important detail I'd like to let you know. The entire album was produced using only #Bitwig, no third-party #VST, in particular their #PolyGrid which enabled all the basslines and synth sounds. Some of them are altered presets, others were built from scratch. I can only praise the possibilities #BitwigStudio offers for production. I made excessive use of #Modulators which means that I didn't mouse draw. I love it.🔥
ShadowInTheVoidDec 26, 2022
These guys don't get enough love. Only 2 real designs for #Modulators but I loved them so much I had to get the full set.
The fact they make little bases for the #Micromasters and the Micromasters can become their weapons too is just really fun.
The Botropolis Rescue Mission set with it's whole Space shuttle base motif has been one of my favorate purchases and you just get so much in that one box.
You can also use these guys to arm up your other bots or make weird combiners too.
#transformers
Emanuel FronhoferNov 4, 2022
Latest #preprint out on #arxiv: #Eco-#evolution from #deep #time to #contemporary dynamics: the role of #timescales and rate #modulators. https://doi.org/10.48550/arXiv.2210.12041
Eco-evolution from deep time to contemporary dynamics: the role of timescales and rate modulators

Eco-evolutionary dynamics, or eco-evolution for short, are thought to involve rapid demography (ecology) and equally rapid phenotypic changes (evolution) leading to novel, emergent system behaviours. This focus on contemporary dynamics is likely due to accumulating evidence for rapid evolution, from classical laboratory microcosms and natural populations, including the iconic Trinidadian guppies. We argue that this view is too narrow, preventing the successful integration of ecology and evolution. While maintaining that eco-evolution involves emergence, we highlight that this may also be true for slow ecology and evolution which unfold over thousands or millions of years, such as the feedbacks between riverine geomorphology and plant evolution. We thereby integrate geomorphology and biome-level feedbacks into eco-evolution, significantly extending its scope. Most importantly, we emphasize that eco-evolutionary systems need not be frozen in state-space: We identify modulators of ecological and evolutionary rates, like temperature or sensitivity to mutation, which can synchronize or desynchronize ecology and evolution. We speculate that global change may increase the occurrence of eco-evolution and emergent system behaviours which represents substantial challenges for prediction. Our perspective represents an attempt to integrate ecology and evolution across disciplines, from gene-regulatory networks to geomorphology and across timescales, from contemporary dynamics to deep time.

arXiv.org