Intracranial electrical stimulation of the #AnteriorInsula decreases risky choice by increasing loss salience, but of the #MedialPrefrontalCortex increases risky choice by decreasing loss salience (causally supporting #AnticipatoryAffect predictions; #Neuroeconomics; #AffectiveNeuroscience):
Direct stimulation of anterior insula and ventromedial prefrontal cortex disrupts economic choices - Nature Communications
Activity in the vmPFC and anterior insula is associated with economic choice and confidence, but their causal involvement is unclear. Here, the authors show that intracranial stimulation of subregions of these areas has distinct effects on risk-taking, loss sensitivity and confidence judgments.