Amelia Cervera 🧬Aug 28, 2025

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate.

#Transposons #Epigenetics #HistoneMarks #H3K9me2 #NuclearPeriphery #Lamins #MouseEmbryonicStemCells

https://www.nature.com/articles/s41556-025-01703-z

The nuclear periphery confers repression on H3K9me2-marked genes and transposons to shape cell fate - Nature Cell Biology

Marin et al. report the role of lamin proteins and the lamin B receptor (LBR) in chromatin positioning at the nuclear periphery. Knockout of all lamins and LBR in mouse embryonic stem cells leads to heterochromatin detachment and derepression of gene and transposon expression.

Nature
Victoria Stuart 🇨🇦 🏳️‍⚧️Jul 18, 2025

Functional genetics - Remembering the Incredible Life of DIY Geneticist Jill Viles
https://www.propublica.org/article/remembering-jill-viles-diy-geneticist-muscular-dystrophy-david-espstein

The DIY Scientist, the Olympian, & the Mutated Gene
https://www.propublica.org/article/muscular-dystrophy-patient-olympic-medalist-same-genetic-mutation

* woman whose muscles disappeared shared a disease w. muscle-bound Olympic medalist

https://en.wikipedia.org/wiki/Jill_Viles

#MuscularDystrophy #genetics #FunctionalGenetics #lamins #LMNA

The Most Interesting Email I Ever Received: Remembering the Incredible Life of DIY Geneticist Jill Viles

In 2013, ProPublica reporter David Epstein was contacted by a woman with a wild story and a batch of photos she believed were clues to the mystery of her condition. Turns out, she was right.

ProPublica