
Postdoc position in Neurobiology
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
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Postdoc position in Neurobiology
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobRxiv
Postdoc position in Neurobiology
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobRxiv
Postdoc position in Neurobiology
Post a job in 3min, or find thousands of job offers like this one at jobRxiv!
jobRxiv

Transposon-mediated genic rearrangements underlie variation in small RNA pathways
Transposable elements (TEs) can alter host gene structure and expression, whereas host organisms develop mechanisms to repress TE activities. In the nematode Caenorhabditis elegans, a small interfering RNA pathway dependent on the helicase ERI-6/7 primarily silences retrotransposons and recent genes of likely viral origin. By studying gene expression variation among wild C. elegans strains, we found that structural variants and transposon remnants likely underlie expression variation in eri-6/7 and the pathway targets. We further found that multiple insertions of the DNA transposons, Polintons, reshuffled the eri-6/7 locus and induced inversion of eri-6 in some wild strains. In the inverted configuration, gene function was previously shown to be repaired by unusual trans-splicing mediated by direct repeats. We identified that these direct repeats originated from terminal inverted repeats of Polintons. Our findings highlight the role of host-transposon interactions in driving rapid host genome diversification among natural populations and shed light on evolutionary novelty in genes and splicing mechanisms.
IDEEVThe Institute of Biology of the École Normale Supérieure
#IBENS is recruiting group leaders in
#computational #biology and
#PlantScienceJunior and Senior applications will be considered for
#compbio group.
Details here:
https://www.biologie.ens.fr/depbio/spip.php?article896Great environment for science!
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Hiring new teams at IBENS in Computational Biology and Plant (...) - ENS - Départment de biologie
The Institute of Biology of the École Normale Supérieure, IBENS is seeking to recruit new group leaders in Computational Biology and Plant (...)