Keiran RowellDec 15, 2024

https://youtube.com/watch?v=Xe-83tBcxhs

Computer #ErrorCorrection codes have nothing on the #DNA repair ballet that keeps your genetic information consistent across all your cells under constant chemical and energetic stress.

This entry into Drew Berry's animations for #WEHI show with crystal clarity how a single nick sends off a controlled series of helix unwinding, bit complement checking and formation of a #HollidayJunctions, during repair.

Do yourself a favour and give it the few minutes watch time 🧬

DNA Break Repair by Homologous Recombination (2024) Drew Berry wehi.tv

Homologous recombination is crucial in repairing double-strand breaks in DNA, correcting errors, and maintaining genomic integrity.This animation highlights ...

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PLOS BiologyApr 24, 2023
Crossovers during #meiosis result from biased resolution of #HollidayJunctions; this study presents genetic evidence that the #nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation #PLOSBiology https://plos.io/40tKoXN
Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis

Crossovers between homologous chromosomes in meiosis result from biased resolution of Holliday junction intermediates, but can DNA nicks present in Holliday junctions provide the appropriate information? This study presents genetic evidence that the nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation.

PLOS BiologyApr 24, 2023
Crossovers during #meiosis result from biased resolution of #HollidayJunctions; this study presents genetic evidence that the #nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation #PLOSBiology https://plos.io/40tKoXN
Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis

Crossovers between homologous chromosomes in meiosis result from biased resolution of Holliday junction intermediates, but can DNA nicks present in Holliday junctions provide the appropriate information? This study presents genetic evidence that the nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation.

PLOS BiologyApr 24, 2023
Crossovers during #meiosis result from biased resolution of #HollidayJunctions; this study presents genetic evidence that the #nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation #PLOSBiology https://plos.io/40tKoXN
Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis

Crossovers between homologous chromosomes in meiosis result from biased resolution of Holliday junction intermediates, but can DNA nicks present in Holliday junctions provide the appropriate information? This study presents genetic evidence that the nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation.