PLOS BiologyApr 23, 2025
Evolutionary analysis of the #nuclease Artemis suggests an important role in the domestication of RAG-like #transposons, such as that which gave rise to V(D)J recombination. Conserved residues crucial for nuclease activity are also identified @PLOSBiology https://plos.io/3RuyNpl
Cross-species analysis of the nuclease Artemis highlights its evolving function in domesticating RAG-like transposons and residues that are crucial for activity

This study reports evolutionary analyses of the nuclease Artemis, suggesting that it played an important role in the domestication of RAG-like transposons, such as the one that gave rise to V(D)J recombination, and identifying several conserved residues that are crucial for nuclease activity.

CellBioNewsAug 23, 2024

Researchers discover #gene scissors that switch off with a built-in timer.

#CRISPR #SAVED #nuclease

https://phys.org/news/2024-08-gene-scissors-built-timer.html

Researchers discover gene scissors that switch off with a built-in timer

CRISPR gene scissors, as new tools of molecular biology, have their origin in an ancient bacterial immune system. But once a virus attack has been successfully overcome, the cell has to recover.

Phys.org
CellBioNewsMay 19, 2024

Researchers use #machine_learning modeling tools to improve #zinc_finger #nuclease #editing technology.

#ZFN #genomes

https://phys.org/news/2024-05-machine-tools-zinc-finger-nuclease.html

Researchers use machine-learning modeling tools to improve zinc-finger nuclease editing technology

Genome editing is making inroads into biomedical research and medicine. By employing biomolecule modeling tools, a Japanese research team is accelerating the pace and cutting the cost of zinc finger nuclease (ZFN) technology, a primary gene editing tool.

Phys.org
CellBioNewsMay 4, 2023

Snapshots of the smallest programmable #nuclease #TnpB published.

#Cas #CRISPR

https://phys.org/news/2023-05-snapshots-smallest-programmable-nuclease-tnpb.html

Snapshots of the smallest programmable nuclease TnpB published

A team led by Professor Virginijus Šikšnys from Vilnius University Life Sciences Center (VU LSC) determined the structure of TnpB using cryo-electron microscopy in collaboration with the group of Professor Guillermo Montoya at the Novo Nordisk Foundation Center for Protein Research (CPR) at the University of Copenhagen.

Phys.org
Phys.orgMay 4, 2023

Referenced link: https://phys.org/news/2023-05-snapshots-smallest-programmable-nuclease-tnpb.html
Discuss on https://discu.eu/q/https://phys.org/news/2023-05-snapshots-smallest-programmable-nuclease-tnpb.html

Originally posted by Phys.org / @physorg_com: http://nitter.platypush.tech/physorg_com/status/1654143176364498945#m

Snapshots of the smallest programmable #nuclease TnpB published @VU_LT @nature https://www.nature.com/articles/s41586-023-05826-x https://phys.org/news/2023-05-snapshots-smallest-programmable-nuclease-tnpb.html

Snapshots of the smallest programmable nuclease TnpB published

A team led by Professor Virginijus Šikšnys from Vilnius University Life Sciences Center (VU LSC) determined the structure of TnpB using cryo-electron microscopy in collaboration with the group of Professor Guillermo Montoya at the Novo Nordisk Foundation Center for Protein Research (CPR) at the University of Copenhagen.

Phys.org
PLOS BiologyApr 24, 2023
Crossovers during #meiosis result from biased resolution of #HollidayJunctions; this study presents genetic evidence that the #nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation #PLOSBiology https://plos.io/40tKoXN
Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis

Crossovers between homologous chromosomes in meiosis result from biased resolution of Holliday junction intermediates, but can DNA nicks present in Holliday junctions provide the appropriate information? This study presents genetic evidence that the nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation.

PLOS BiologyApr 24, 2023
Crossovers during #meiosis result from biased resolution of #HollidayJunctions; this study presents genetic evidence that the #nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation #PLOSBiology https://plos.io/40tKoXN
Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis

Crossovers between homologous chromosomes in meiosis result from biased resolution of Holliday junction intermediates, but can DNA nicks present in Holliday junctions provide the appropriate information? This study presents genetic evidence that the nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation.

PLOS BiologyApr 24, 2023
Crossovers during #meiosis result from biased resolution of #HollidayJunctions; this study presents genetic evidence that the #nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation #PLOSBiology https://plos.io/40tKoXN
Exo1 protects DNA nicks from ligation to promote crossover formation during meiosis

Crossovers between homologous chromosomes in meiosis result from biased resolution of Holliday junction intermediates, but can DNA nicks present in Holliday junctions provide the appropriate information? This study presents genetic evidence that the nuclease Exo1 promotes meiotic crossing over by protecting DNA nicks from ligation.

Helmholtz Institute WürzburgMar 28, 2023
Check out this CRISPR Medicine article highlighting the recent discovery of the #nuclease #Cas12a2, a new type of #CRISPR gene scissors. ✂️🧬
https://crisprmedicinenews.com/news/appetite-for-destruction-the-indiscriminate-nuclease-activity-of-cas12a2/
News: Appetite for Destruction: The Indiscriminate Nuclease Activity of Cas12a2 - CRISPR Medicine

Researchers from Utah State University and Germany’s Helmholtz Institute for RNA-based Infection Research demonstrate that upon recognition of an RNA target, Cas12a2 cleaves all the other nucleic acids present, destroying the bacterial cell and preventing bacteriophage from replicating.

CRISPR Medicine
CellBioNewsFeb 24, 2023

A #molecular machine's secret weapon exposed.

#RNA #mutations #Dis3L2 #nuclease

https://phys.org/news/2023-02-molecular-machine-secret-weapon-exposed.html

A molecular machine's secret weapon exposed

RNAs are having a moment. The foundation of COVID-19 vaccines, they've made their way from biochemistry textbooks into popular magazines and everyday discussions. Entire companies have been launched that are dedicated to RNA research. These tiny molecules are traditionally known for helping cells make proteins, but they can do much more. They come in many shapes and sizes, from short and simple hairpin loops to long and seemingly tangled arrangements. RNAs can help activate or deactivate genes, change the shape of chromosomes, and even destroy other RNA molecules.

Phys.org