StructBiolCommunicationsCryo-EM structures of the catalytic part of human HMG-CoA reductase in the apo form and bound to atorvastatin, a commonly used drug in cardiovascular disease, are reported at resolutions of 2.1 and 2.3 Å, respectively #SPACryoEM #HHMGR #Atorvastatin https://doi.org/10.1107/S2053230X25001098
Cryo-EM structures of apo and atorvastatin-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase
Single-particle cryo-EM structures of apo and atorvastation-bound human 3-hydroxy-3-methylglutaryl-coenzyme A reductase were determined using graphene oxide-coated grids.